A thermodynamic analysis of the Collander equation and establishment of a reference solvent for use in drug partitioning studies

A thermodynamic analysis of the Collander equation, ln PI = a + b ln PII (I and II refer to two different partitioning systems with partition coefficients PI and PII, respectively), is given and applied to three forms of correlation. The intercept, a, is shown to have no general fundamental signific...

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Bibliographic Details
Published inJournal of pharmacy and pharmacology Vol. 39; no. 10; p. 774
Main Authors Beezer, A E, Gooch, C A, Hunter, W H, Volpe, P L
Format Journal Article
LanguageEnglish
Published England 01.10.1987
Subjects
Liposomes
Pharmaceutical Preparations - analysis
Reference Values
Solubility
Solvents
Thermodynamics
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Summary:A thermodynamic analysis of the Collander equation, ln PI = a + b ln PII (I and II refer to two different partitioning systems with partition coefficients PI and PII, respectively), is given and applied to three forms of correlation. The intercept, a, is shown to have no general fundamental significance whereas the slope, b is shown to reflect differences in non-aqueous solvent properties; b is also shown to be of use in scaling solvent behaviour to select solvents which closely represent biological membrane properties for use in partitioning studies. Laboratory and literature data are subjected to the analysis.
ISSN:0022-3573
2042-7158
DOI:10.1111/j.2042-7158.1987.tb05118.x