Polymorphisms in the hANP (Human Atrial Natriuretic Peptide) Gene, Albuminuria, and Hypertension

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 37; no. 6; pp. 1416 - 1422
• Main Authors: Nannipieri, Monica, Manganiello, Mascia, Pezzatini, Anna, De Bellis, Alessandra, Seghieri, Giuseppe, Ferrannini, Ele
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.06.2001; Hagerstown, MD Lippincott
• Subjects: Adult; Aged; Albuminuria - genetics; Arterial hypertension. Arterial hypotension; Atrial Natriuretic Factor - genetics; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Cohort Studies; Deoxyribonucleases, Type II Site-Specific - chemistry; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 2 - complications; Female; Gene Frequency; Genes; Genetic Predisposition to Disease; Humans; Hypertension, Renal - genetics; Male; Medical sciences; Middle Aged; Polymorphism, Genetic; Endocrinopathy; Human; Hypertension; Urinary system disease; Pathophysiology; Pathogenesis; Diabetes mellitus; Albumin; Cardiovascular disease; Exploration; Genotype; Atrial natriuretic peptide; Genetic determinism; Allele; Concomitant disease; Phenotype; Gene; Complication; Mutation; Comparative study; Microalbuminuria; Proteinuria; Polymorphism

Atrial natriuretic peptide (ANP) jointly affects kidney function and blood pressure homeostasis and is a candidate susceptibility gene for both essential hypertension and kidney disease. We evaluated the relation between the ScaI and BstXI polymorphisms of the human ANP (hANP) gene, hypertension, an...