Adjacent Segment Degeneration After Anterior Cervical Discectomy and Fusion With an Autologous Iliac Crest Graft: A Magnetic Resonance Imaging Study of 59 Patients With a Mean Follow-up of 27 Years

• Published in: Neurosurgery Vol. 82; no. 6; pp. 799 - 807
• Main Authors: Burkhardt, Benedikt W, Simgen, Andreas, Wagenpfeil, Gudrun, Reith, Wolfgang, Oertel, Joachim M
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.06.2018; Copyright by the Congress of Neurological Surgeons; Wolters Kluwer Health, Inc
• Subjects: Adult; Aged; Bone Transplantation - adverse effects; Bone Transplantation - methods; Cervical Vertebrae - diagnostic imaging; Cervical Vertebrae - pathology; Cervical Vertebrae - surgery; Decompression, Surgical - adverse effects; Decompression, Surgical - methods; Diskectomy - adverse effects; Diskectomy - methods; Female; Follow-Up Studies; Humans; Ilium - surgery; Intervertebral Disc Degeneration - surgery; Magnetic Resonance Imaging; Male; Middle Aged; Neurosurgery; Physiology; Postoperative Complications - diagnostic imaging; Postoperative Complications - etiology; Postoperative Complications - pathology; Retrospective Studies; Spinal Fusion - adverse effects; Spinal Fusion - methods; Spine; Surgical techniques; Long-term follow-up; Magnetic resonance imaging; MRI; ACDF; Cervical disc height; Adjacent segment degeneration; Cervical spine
• ISSN: 0148-396X; 1524-4040; 1524-4040
• DOI: 10.1093/neuros/nyx304

Abstract BACKGROUND Anterior cervical decompression and fusion (ACDF) is a widely accepted surgical technique for the treatment of degenerative disc disease. ACDF is associated with adjacent segment degeneration (ASD). OBJECTIVE To assess whether physiological aging of the spine would overcome ASD by comparing adjacent to adjoining segments more than 18 yr after ACDF. METHODS Magnetic resonance imaging of 59 (36 male, 23 female) patients who underwent ACDF was performed to assess degeneration. The mean follow-up was 27 yr (18-45 yr). Besides measuring the disc height, a 5-step grading system (segmental degeneration index [SDI]) including disc signal intensity, anterior and posterior disc protrusion, narrowing of the disc space, and foraminal stenosis was used to assess the grade of adjacent and adjoining segments. RESULTS The SDI of cranial and caudal adjacent segments was significantly higher compared to adjoining segments (P < .001). The disc height of cranial and caudal adjacent segments was significantly lower compared to adjoining segments (P < .001, P < .01). The SDI of adjacent segments in patients with repeat cervical procedure was significantly higher than in patients without repeat procedure (P = .02, P = .01). The disc height of the cranial adjacent segments in patients with repeat procedure was significantly lower than in patients without repeat procedure (P = .01). CONCLUSION The physiological aging of the cervical spine does not overcome ASD. The disc height and the SDI in adjacent segment are significantly worse compared to adjoining segments. Patients who underwent repeat procedure had even worse findings of disc height and SDI.