Interpersonal life stress, inflammation, and depression in adolescence: Testing Social Signal Transduction Theory of Depression

• Published in: Depression and anxiety Vol. 37; no. 2; pp. 179 - 193
• Main Authors: Slavich, George M., Giletta, Matteo, Helms, Sarah W., Hastings, Paul D., Rudolph, Karen D., Nock, Matthew K., Prinstein, Mitchell J.
• Format: Journal Article
• Language: English
• Published: United States Hindawi Limited 01.02.2020
• Subjects: Adolescent; Child; Child & adolescent psychiatry; Cytokines; Depression - complications; Depression - immunology; Depression - psychology; development; disease; Female; Girls; Humans; Inflammation; Inflammation - complications; Inflammation - immunology; Inflammation - psychology; Interleukin-1beta - analysis; Interleukin-1beta - immunology; Interpersonal Relations; Interviews as Topic; major depressive disorder; Male; Mental depression; Models, Psychological; Psychopathology; risk; Saliva - immunology; Signal transduction; Social interactions; social stress; Stress; Stress, Psychological - complications; Stress, Psychological - immunology; Stress, Psychological - psychology; Teenagers; Tumor Necrosis Factor-alpha - analysis; Tumor Necrosis Factor-alpha - immunology; vulnerability; development; disease; major depressive disorder; inflammation; cytokines; risk; social stress; vulnerability

Background Depression rates increase markedly for girls across the adolescent transition, but the social‐environmental and biological processes underlying this phenomenon remain unclear. To address this issue, we tested a key hypothesis from Social Signal Transduction Theory of Depression, which pos...