Chemical warfare agent simulants for human volunteer trials of emergency decontamination: A systematic review

• Published in: Journal of applied toxicology Vol. 38; no. 1; pp. 113 - 121
• Main Authors: James, Thomas, Wyke, Stacey, Marczylo, Tim, Collins, Samuel, Gaulton, Tom, Foxall, Kerry, Amlôt, Richard, Duarte‐Davidson, Raquel
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.01.2018; John Wiley and Sons Inc
• Subjects: Biological & chemical weapons; Casualties; Chemical agents; Chemical warfare; chemical warfare agent; Chemical warfare agents; Chemical Warfare Agents - chemistry; Chemical Warfare Agents - toxicity; Chemicals; Contaminants; Databases, Factual; Decontamination; Decontamination - methods; Emergencies; emergency; Equivalence; Health risks; Healthy Volunteers; Human subjects; human volunteer trials; Humans; In Vitro Techniques; Injury prevention; Lethal Dose 50; Malathion; Malathion - chemistry; Malathion - toxicity; Malonates - chemistry; Malonates - toxicity; Mustard gas; Physicochemical properties; Properties (attributes); Public health; Review; Reviews; Salicylates - chemistry; Salicylates - toxicity; Salicylic acid; simulant; Soman; Sulfur; Toxicity; simulant; human volunteer trials; emergency; decontamination; chemical warfare agent

Incidents involving the release of chemical agents can pose significant risks to public health. In such an event, emergency decontamination of affected casualties may need to be undertaken to reduce injury and possible loss of life. To ensure these methods are effective, human volunteer trials (HVTs...