Bioavailability of Triprolidine as a Single Agent or in Combination With Pseudoephedrine: A Randomized, Open‐Label Crossover Study in Healthy Volunteers

• Published in: Clinical pharmacology in drug development Vol. 9; no. 4; pp. 486 - 495
• Main Authors: Febbraro, Salvatore, Shea, Tim, Cravo, Ana Santos
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2020; John Wiley and Sons Inc
• Subjects: anticholinergic activity; antihistamines; Bioavailability; cold; common; Drug therapy; Histamine; Original Manuscript; pharmacokinetics; Pharmacology; triprolidine hydrochloride; common; anticholinergic activity; bioavailability; triprolidine hydrochloride; antihistamines; pharmacokinetics; cold

Antihistamines have been in clinical use for more than 70 years to treat allergic and nonallergic symptoms including relief from cold and flu symptoms. Despite their widespread use, pharmacokinetic (PK) data are sparse for older, first‐generation antihistamines. This phase 1 single‐center open‐label...