Longitudinal Assessment of Diagnostic Test Performance Over the Course of Acute SARS-CoV-2 Infection

• Published in: The Journal of infectious diseases Vol. 224; no. 6; pp. 976 - 982
• Main Authors: Smith, Rebecca L, Gibson, Laura L, Martinez, Pamela P, Ke, Ruian, Mirza, Agha, Conte, Madison, Gallagher, Nicholas, Conte, Abigail, Wang, Leyi, Fredrickson, Richard, Edmonson, Darci C, Baughman, Melinda E, Chiu, Karen K, Choi, Hannah, Jensen, Tor W, Scardina, Kevin R, Bradley, Shannon, Gloss, Stacy L, Reinhart, Crystal, Yedetore, Jagadeesh, Owens, Alyssa N, Broach, John, Barton, Bruce, Lazar, Peter, Henness, Darcy, Young, Todd, Dunnett, Alastair, Robinson, Matthew L, Mostafa, Heba H, Pekosz, Andrew, Manabe, Yukari C, Heetderks, William J, McManus, David D, Brooke, Christopher B
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 30.06.2021
• Subjects: Antigens; Coronaviruses; Diagnostic tests; Major and Brief Reports; Medical diagnosis; Polymerase chain reaction; Reverse transcription; Saliva; Severe acute respiratory syndrome coronavirus 2; RT-qPCR testing; SARS-CoV-2; antigen testing; test sensitivity; diagnostic testing

Abstract Background Serial screening is critical for restricting spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by facilitating timely identification of infected individuals to interrupt transmission. Variation in sensitivity of different diagnostic tests at different stages...