Heritability of BDNF alleles and their effect on brain morphology in schizophrenia

• Published in: American journal of medical genetics Vol. 88; no. 6; p. 724
• Main Authors: Wassink, T H, Nelson, J J, Crowe, R R, Andreasen, N C
• Format: Journal Article
• Language: English
• Published: United States 15.12.1999
• Subjects: Adult; Age of Onset; Alleles; Brain - metabolism; Brain - pathology; Brain-Derived Neurotrophic Factor - genetics; Brain-Derived Neurotrophic Factor - physiology; Case-Control Studies; Female; Genetic Predisposition to Disease; Genetic Variation - genetics; Haplotypes - genetics; Humans; Logistic Models; Male; Polymorphism, Genetic - genetics; Schizophrenia - genetics; Schizophrenia - pathology

Accumulating evidence suggests that disturbed brain development may play a role in the etiology of schizophrenia, and that the illness is, to a significant degree, heritable. We therefore investigated brain derived neurotrophic factor (BDNF), a neurotrophin expressed in fetal brain, as a candidate d...