Pharmacokinetic Evaluation of CYP3A4‐Mediated Drug‐Drug Interactions of Isavuconazole With Rifampin, Ketoconazole, Midazolam, and Ethinyl Estradiol/Norethindrone in Healthy Adults - Townsend, Robert; Dietz, Albert; Hale, Christine; Akhtar, Shahzad; Kowalski, Donna; Lademacher, Christopher; Lasseter, Kenneth; Pearlman, Helene; Rammelsberg, Diane; Schmitt‐Hoffmann, Anne; Yamazaki, Takao; Desai, Amit (Clinical pharmacology in drug development, 2017)
Keywords: Adult; Antifungal Agents - administration & dosage; Antifungal Agents - pharmacokinetics; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP3A - metabolism; Drug Interactions; ethinyl estradiol/norethindrone; Female; Healthy Volunteers; Humans; isavuconazole; ketoconazole; Ketoconazole - administration & dosage; Male; Metabolism; midazolam; Midazolam - administration & dosage; Middle Aged; Nitriles - administration & dosage; Nitriles - pharmacokinetics; Norethindrone - administration & dosage; Original Manuscript; Prescription drugs; Pyridines - administration & dosage; Pyridines - pharmacokinetics; rifampin; Rifampin - administration & dosage; Side effects; Triazoles - administration & dosage; Triazoles - pharmacokinetics; ethinyl estradiol/norethindrone; ketoconazole; isavuconazole; midazolam; rifampin