Sensitive CE‐MS method for monitoring of riociguat and desmethylriociguat levels in human serum - Hložek, Tomáš; Štícha, Martin; Bursová, Miroslava; Jelínek, Ivan; Tůma, Petr; Čabala, Radomír (Electrophoresis, 2020)
Keywords: ammonium; Analytical chemistry; antihypertensive agents; Antihypertensives; blood serum; calibration; Capillary electrophoresis; chemical species; Desmethylriociguat; Determination; Electrolytes; Electrophoresis; Electrophoresis, Capillary - methods; formates; High performance liquid chromatography; Humans; Hypertension; Limit of Detection; Linear Models; Liquid-Liquid Extraction; Mass spectrometry; Optimization; Pharmacokinetics; Pharmacology; Pretreatment; Pyrazoles - blood; Pyrazoles - chemistry; Pyrazoles - isolation & purification; Pyrazoles - pharmacokinetics; Pyrimidines - blood; Pyrimidines - chemistry; Pyrimidines - isolation & purification; Pyrimidines - pharmacokinetics; Reproducibility of Results; Riociguat; Scientific imaging; Spectrometry, Mass, Electrospray Ionization - methods; Spectroscopy; Desmethylriociguat; Determination; Capillary electrophoresis; Mass spectrometry; Riociguat