Pharmacokinetic Assessment of Drug‐Drug Interactions of Isavuconazole With the Immunosuppressants Cyclosporine, Mycophenolic Acid, Prednisolone, Sirolimus, and Tacrolimus in Healthy Adults

• Published in: Clinical pharmacology in drug development Vol. 6; no. 1; pp. 76 - 85
• Main Authors: Groll, Andreas H., Desai, Amit, Han, David, Howieson, Corrie, Kato, Kota, Akhtar, Shahzad, Kowalski, Donna, Lademacher, Christopher, Lewis, William, Pearlman, Helene, Mandarino, Debra, Yamazaki, Takao, Townsend, Robert
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2017; John Wiley and Sons Inc
• Subjects: Acids; Adult; Area Under Curve; cyclosporine; Cyclosporine - administration & dosage; Drug dosages; Drug Interactions; Female; Healthy Volunteers; Humans; isavuconazole; Male; Middle Aged; mycophenolate mofetil; Mycophenolic Acid - administration & dosage; Nitriles - administration & dosage; Nitriles - pharmacokinetics; Original Manuscript; prednisolone; Prednisolone - administration & dosage; Prescription drugs; Pyridines - administration & dosage; Pyridines - pharmacokinetics; sirolimus; Sirolimus - administration & dosage; tacrolimus; Tacrolimus - administration & dosage; Triazoles - administration & dosage; Triazoles - pharmacokinetics; Young Adult; cyclosporine; prednisolone; mycophenolate mofetil; isavuconazole; tacrolimus; sirolimus

This report summarizes phase 1 studies that evaluated pharmacokinetic interactions between the novel triazole antifungal agent isavuconazole and the immunosuppressants cyclosporine, mycophenolic acid, prednisolone, sirolimus, and tacrolimus in healthy adults. Healthy subjects received single oral do...