Assessment of systemic genetic damage in pediatric inflammatory bowel disease

• Published in: Environmental and molecular mutagenesis Vol. 61; no. 9; pp. 901 - 909
• Main Authors: Baig, Ayesha, Avlasevich, Svetlana L., Torous, Dorothea K., Bemis, Jeffrey C., Saubermann, Lawrence J., Lovell, David P., MacGregor, James T., Dertinger, Stephen D.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.11.2020; Wiley Subscription Services, Inc
• Subjects: Adolescent; Adult; Antigens, CD - genetics; Blood cells; CD59 antigen; CD59 Antigens - genetics; Cell Adhesion Molecules - genetics; Child; chromosomal damage; Chromosome aberrations; Constipation; Damage; Etiology; Female; genotoxicity; flow cytometry; Humans; Inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory Bowel Diseases - genetics; Inflammatory Bowel Diseases - pathology; Intestine; Irritable bowel syndrome; Male; Membrane Proteins - genetics; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mutation; Pediatrics; Phenotypes; Reticulocytes; Reticulocytes - metabolism; Reticulocytes - pathology; Tumor necrosis factor; Upper bounds; Young Adult; mutation; chromosomal damage; genotoxicity; flow cytometry; inflammatory bowel disease
• ISSN: 0893-6692; 1098-2280; 1098-2280
• DOI: 10.1002/em.22403

The etiology of distal site cancers in inflammatory bowel disease (IBD) is not well understood and requires further study. We investigated whether pediatric IBD patients' blood cells exhibit elevated levels of genomic damage by measuring the frequency of mutant phenotype (CD59‐/CD55‐) reticuloc...