Argyrophilic Grain Disease: Demographics, Clinical, and Neuropathological Features From a Large Autopsy Study

Argyrophilic grain disease (AGD) is a frequent late-onset, 4-repeat tauopathy reported in Caucasians with high educational attainment. Little is known about AGD in non-Caucasians or in those with low educational attainment. We describe AGD demographics, clinical, and neuropathological features in a...

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Published inJournal of neuropathology and experimental neurology Vol. 75; no. 7; pp. 628 - 635
Main Authors Rodriguez, Roberta Diehl, Suemoto, Claudia Kimie, Molina, Mariana, Nascimento, Camila Fernandes, Leite, Renata Elaine Paraizo, de Lucena Ferretti-Rebustini, Renata Eloah, Farfel, José Marcelo, Heinsen, Helmut, Nitrini, Ricardo, Ueda, Kenji, Pasqualucci, Carlos Augusto, Jacob-Filho, Wilson, Yaffe, Kristine, Grinberg, Lea Tenenholz
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.07.2016
by American Association of Neuropathologists, Inc
Subjects
Aged
Aged, 80 and over
Autopsy
Brazil - epidemiology
Demography - methods
Female
Humans
Male
Middle Aged
Neurodegenerative Diseases - epidemiology
Neurodegenerative Diseases - pathology
Neurodegenerative Diseases - psychology
Original
Tauopathies - epidemiology
Tauopathies - pathology
Tauopathies - psychology
Tauopathy
Neurodegeneration
Neuropathology
Postmortem
Dementia
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Abstract Argyrophilic grain disease (AGD) is a frequent late-onset, 4-repeat tauopathy reported in Caucasians with high educational attainment. Little is known about AGD in non-Caucasians or in those with low educational attainment. We describe AGD demographics, clinical, and neuropathological features in a multiethnic cohort of 983 subjects ≥50 years of age from São Paulo, Brazil. Clinical data were collected through semistructured interviews with an informant and included in the Informant Questionnaire on Cognitive Decline in the Elderly, the Clinical Dementia Rating, and the Neuropsychiatric Inventory. Neuropathologic assessment relied on internationally accepted criteria. AGD was frequent (15.2%) and was the only neuropathological diagnosis in 8.9% of all cases (mean, 78.9 ± 9.4 years); it rarely occurred as an isolated neuropathological finding. AGD was associated with older age, lower socioeconomic status (SES), and appetite disorders. This is the first study of demographic, clinical, and neuropathological aspects of AGD in different ethnicities and subjects from all socioeconomic strata. The results suggest that prospective studies of AGD patients include levels of hormones related to appetite control as possible antemortem markers. Moreover, understanding the mechanisms behind higher susceptibility to AGD of low SES subjects may disclose novel environmental risk factors for AGD and other neurodegenerative diseases.
AbstractList Argyrophilic grain disease (AGD) is a frequent late-onset, 4-repeat tauopathy reported in Caucasians with high educational attainment. Little is known about AGD in non-Caucasians or in those with low educational attainment. We describe AGD demographics, clinical, and neuropathological features in a multiethnic cohort of 983 subjects ≥50 years of age from São Paulo, Brazil. Clinical data were collected through semistructured interviews with an informant and included in the Informant Questionnaire on Cognitive Decline in the Elderly, the Clinical Dementia Rating, and the Neuropsychiatric Inventory. Neuropathologic assessment relied on internationally accepted criteria. AGD was frequent (15.2%) and was the only neuropathological diagnosis in 8.9% of all cases (mean, 78.9 ± 9.4 years); it rarely occurred as an isolated neuropathological finding. AGD was associated with older age, lower socioeconomic status (SES), and appetite disorders. This is the first study of demographic, clinical, and neuropathological aspects of AGD in different ethnicities and subjects from all socioeconomic strata. The results suggest that prospective studies of AGD patients include levels of hormones related to appetite control as possible antemortem markers. Moreover, understanding the mechanisms behind higher susceptibility to AGD of low SES subjects may disclose novel environmental risk factors for AGD and other neurodegenerative diseases.
Author Pasqualucci, Carlos Augusto
Grinberg, Lea Tenenholz
Jacob-Filho, Wilson
Yaffe, Kristine
Ueda, Kenji
Molina, Mariana
de Lucena Ferretti-Rebustini, Renata Eloah
Leite, Renata Elaine Paraizo
Heinsen, Helmut
Suemoto, Claudia Kimie
Farfel, José Marcelo
Rodriguez, Roberta Diehl
Nascimento, Camila Fernandes
Nitrini, Ricardo
AuthorAffiliation From the Discipline of Pathophysiology (RDR, MM, CFN), Behavioral and Cognitive Neurology Unit, Department of Neurology (RDR, RN), Brazilian Brain Bank of the Aging Brain Study Group, LIM-22 (CKS, REPL, REdLF-R, JMF, HH, RN, CAP, WJ-F, LTG), Discipline of Geriatrics, University of São Paulo, São Paulo, Brazil (CKS, REPL, JMF, WJ-F); Medical-Surgical Nursing Department, University of São Paulo School of Nursing, São Paulo, Brazil (REdLF-R); Department of Pathology, University of São Paulo, São Paulo, Brazil (HH, CAP, LTG); Department of Psychiatry, Morphological Brain Research Unit, University of Würzburg, Würzburg, Germany (HH); Department of Neurochemistry, Tokyo Institute of Psychiatry, Setagaya-ku/Tokyo, Japan (KU); Memory and Aging Center, Department of Neurology and Pathology (KY, LTG); and Department of Psychiatry, University of California, San Francisco, California (KY)
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  givenname: Roberta Diehl
  surname: Rodriguez
  fullname: Rodriguez, Roberta Diehl
  organization: From the Discipline of Pathophysiology (RDR, MM, CFN), Behavioral and Cognitive Neurology Unit, Department of Neurology (RDR, RN), Brazilian Brain Bank of the Aging Brain Study Group, LIM-22 (CKS, REPL, REdLF-R, JMF, HH, RN, CAP, WJ-F, LTG), Discipline of Geriatrics, University of São Paulo, São Paulo, Brazil (CKS, REPL, JMF, WJ-F); Medical-Surgical Nursing Department, University of São Paulo School of Nursing, São Paulo, Brazil (REdLF-R); Department of Pathology, University of São Paulo, São Paulo, Brazil (HH, CAP, LTG); Department of Psychiatry, Morphological Brain Research Unit, University of Würzburg, Würzburg, Germany (HH); Department of Neurochemistry, Tokyo Institute of Psychiatry, Setagaya-ku/Tokyo, Japan (KU); Memory and Aging Center, Department of Neurology and Pathology (KY, LTG); and Department of Psychiatry, University of California, San Francisco, California (KY)
– sequence: 2
  givenname: Claudia Kimie
  surname: Suemoto
  fullname: Suemoto, Claudia Kimie
  organization: From the Discipline of Pathophysiology (RDR, MM, CFN), Behavioral and Cognitive Neurology Unit, Department of Neurology (RDR, RN), Brazilian Brain Bank of the Aging Brain Study Group, LIM-22 (CKS, REPL, REdLF-R, JMF, HH, RN, CAP, WJ-F, LTG), Discipline of Geriatrics, University of São Paulo, São Paulo, Brazil (CKS, REPL, JMF, WJ-F); Medical-Surgical Nursing Department, University of São Paulo School of Nursing, São Paulo, Brazil (REdLF-R); Department of Pathology, University of São Paulo, São Paulo, Brazil (HH, CAP, LTG); Department of Psychiatry, Morphological Brain Research Unit, University of Würzburg, Würzburg, Germany (HH); Department of Neurochemistry, Tokyo Institute of Psychiatry, Setagaya-ku/Tokyo, Japan (KU); Memory and Aging Center, Department of Neurology and Pathology (KY, LTG); and Department of Psychiatry, University of California, San Francisco, California (KY)
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  givenname: Mariana
  surname: Molina
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  organization: From the Discipline of Pathophysiology (RDR, MM, CFN), Behavioral and Cognitive Neurology Unit, Department of Neurology (RDR, RN), Brazilian Brain Bank of the Aging Brain Study Group, LIM-22 (CKS, REPL, REdLF-R, JMF, HH, RN, CAP, WJ-F, LTG), Discipline of Geriatrics, University of São Paulo, São Paulo, Brazil (CKS, REPL, JMF, WJ-F); Medical-Surgical Nursing Department, University of São Paulo School of Nursing, São Paulo, Brazil (REdLF-R); Department of Pathology, University of São Paulo, São Paulo, Brazil (HH, CAP, LTG); Department of Psychiatry, Morphological Brain Research Unit, University of Würzburg, Würzburg, Germany (HH); Department of Neurochemistry, Tokyo Institute of Psychiatry, Setagaya-ku/Tokyo, Japan (KU); Memory and Aging Center, Department of Neurology and Pathology (KY, LTG); and Department of Psychiatry, University of California, San Francisco, California (KY)
– sequence: 4
  givenname: Camila Fernandes
  surname: Nascimento
  fullname: Nascimento, Camila Fernandes
  organization: From the Discipline of Pathophysiology (RDR, MM, CFN), Behavioral and Cognitive Neurology Unit, Department of Neurology (RDR, RN), Brazilian Brain Bank of the Aging Brain Study Group, LIM-22 (CKS, REPL, REdLF-R, JMF, HH, RN, CAP, WJ-F, LTG), Discipline of Geriatrics, University of São Paulo, São Paulo, Brazil (CKS, REPL, JMF, WJ-F); Medical-Surgical Nursing Department, University of São Paulo School of Nursing, São Paulo, Brazil (REdLF-R); Department of Pathology, University of São Paulo, São Paulo, Brazil (HH, CAP, LTG); Department of Psychiatry, Morphological Brain Research Unit, University of Würzburg, Würzburg, Germany (HH); Department of Neurochemistry, Tokyo Institute of Psychiatry, Setagaya-ku/Tokyo, Japan (KU); Memory and Aging Center, Department of Neurology and Pathology (KY, LTG); and Department of Psychiatry, University of California, San Francisco, California (KY)
– sequence: 5
  givenname: Renata Elaine Paraizo
  surname: Leite
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  organization: From the Discipline of Pathophysiology (RDR, MM, CFN), Behavioral and Cognitive Neurology Unit, Department of Neurology (RDR, RN), Brazilian Brain Bank of the Aging Brain Study Group, LIM-22 (CKS, REPL, REdLF-R, JMF, HH, RN, CAP, WJ-F, LTG), Discipline of Geriatrics, University of São Paulo, São Paulo, Brazil (CKS, REPL, JMF, WJ-F); Medical-Surgical Nursing Department, University of São Paulo School of Nursing, São Paulo, Brazil (REdLF-R); Department of Pathology, University of São Paulo, São Paulo, Brazil (HH, CAP, LTG); Department of Psychiatry, Morphological Brain Research Unit, University of Würzburg, Würzburg, Germany (HH); Department of Neurochemistry, Tokyo Institute of Psychiatry, Setagaya-ku/Tokyo, Japan (KU); Memory and Aging Center, Department of Neurology and Pathology (KY, LTG); and Department of Psychiatry, University of California, San Francisco, California (KY)
– sequence: 6
  givenname: Renata Eloah
  surname: de Lucena Ferretti-Rebustini
  fullname: de Lucena Ferretti-Rebustini, Renata Eloah
  organization: From the Discipline of Pathophysiology (RDR, MM, CFN), Behavioral and Cognitive Neurology Unit, Department of Neurology (RDR, RN), Brazilian Brain Bank of the Aging Brain Study Group, LIM-22 (CKS, REPL, REdLF-R, JMF, HH, RN, CAP, WJ-F, LTG), Discipline of Geriatrics, University of São Paulo, São Paulo, Brazil (CKS, REPL, JMF, WJ-F); Medical-Surgical Nursing Department, University of São Paulo School of Nursing, São Paulo, Brazil (REdLF-R); Department of Pathology, University of São Paulo, São Paulo, Brazil (HH, CAP, LTG); Department of Psychiatry, Morphological Brain Research Unit, University of Würzburg, Würzburg, Germany (HH); Department of Neurochemistry, Tokyo Institute of Psychiatry, Setagaya-ku/Tokyo, Japan (KU); Memory and Aging Center, Department of Neurology and Pathology (KY, LTG); and Department of Psychiatry, University of California, San Francisco, California (KY)
– sequence: 7
  givenname: José Marcelo
  surname: Farfel
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– sequence: 8
  givenname: Helmut
  surname: Heinsen
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  givenname: Kenji
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  givenname: Carlos Augusto
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  givenname: Wilson
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– sequence: 13
  givenname: Kristine
  surname: Yaffe
  fullname: Yaffe, Kristine
  organization: From the Discipline of Pathophysiology (RDR, MM, CFN), Behavioral and Cognitive Neurology Unit, Department of Neurology (RDR, RN), Brazilian Brain Bank of the Aging Brain Study Group, LIM-22 (CKS, REPL, REdLF-R, JMF, HH, RN, CAP, WJ-F, LTG), Discipline of Geriatrics, University of São Paulo, São Paulo, Brazil (CKS, REPL, JMF, WJ-F); Medical-Surgical Nursing Department, University of São Paulo School of Nursing, São Paulo, Brazil (REdLF-R); Department of Pathology, University of São Paulo, São Paulo, Brazil (HH, CAP, LTG); Department of Psychiatry, Morphological Brain Research Unit, University of Würzburg, Würzburg, Germany (HH); Department of Neurochemistry, Tokyo Institute of Psychiatry, Setagaya-ku/Tokyo, Japan (KU); Memory and Aging Center, Department of Neurology and Pathology (KY, LTG); and Department of Psychiatry, University of California, San Francisco, California (KY)
– sequence: 14
  givenname: Lea Tenenholz
  surname: Grinberg
  fullname: Grinberg, Lea Tenenholz
  email: lea.grinberg@ucsf.edu
  organization: From the Discipline of Pathophysiology (RDR, MM, CFN), Behavioral and Cognitive Neurology Unit, Department of Neurology (RDR, RN), Brazilian Brain Bank of the Aging Brain Study Group, LIM-22 (CKS, REPL, REdLF-R, JMF, HH, RN, CAP, WJ-F, LTG), Discipline of Geriatrics, University of São Paulo, São Paulo, Brazil (CKS, REPL, JMF, WJ-F); Medical-Surgical Nursing Department, University of São Paulo School of Nursing, São Paulo, Brazil (REdLF-R); Department of Pathology, University of São Paulo, São Paulo, Brazil (HH, CAP, LTG); Department of Psychiatry, Morphological Brain Research Unit, University of Würzburg, Würzburg, Germany (HH); Department of Neurochemistry, Tokyo Institute of Psychiatry, Setagaya-ku/Tokyo, Japan (KU); Memory and Aging Center, Department of Neurology and Pathology (KY, LTG); and Department of Psychiatry, University of California, San Francisco, California (KY)
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27283329$$D View this record in MEDLINE/PubMed
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Issue 7
Keywords Tauopathy
Neurodegeneration
Neuropathology
Postmortem
Dementia
Language English
License 2016 American Association of Neuropathologists, Inc. All rights reserved.
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Disclosure/conflict of interest: Claudia Kimie Suemoto, Renata Eloah de Lucena Ferretti-Rebustini, José Marcelo Farfel, Helmut Heinsen, Ricardo Nitrini, Carlos Augusto Pasqualucci, Wilson Jacob-Filho, and Kristine Yaffe have no duality or conflicts of interest to declare.
Supplementary Data can be found at http://www.jnen.oxfordjournals.org.
Roberta Diehl Rodriguez was supported by a FAPESP PhD fellowship (2012/07526-5) and by CAPES (99999.012331/2013-09). Mariana Molina was funded by CAPES. Camila Fernandes Nascimento was supported by a FAPESP PhD fellowship (2011/19833-7). Renata Elaine Paraizo Leite was supported by a FAPESP (2010/06521-4). Lea Tenenholz Grinberg was funded by institutional NIH grants P50AG023501, P01AG019724, and R01AG040311.
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PublicationTitle Journal of neuropathology and experimental neurology
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Snippet Argyrophilic grain disease (AGD) is a frequent late-onset, 4-repeat tauopathy reported in Caucasians with high educational attainment. Little is known about...
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SourceType Open Access Repository
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Index Database
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SubjectTerms Aged
Aged, 80 and over
Autopsy
Brazil - epidemiology
Demography - methods
Female
Humans
Male
Middle Aged
Neurodegenerative Diseases - epidemiology
Neurodegenerative Diseases - pathology
Neurodegenerative Diseases - psychology
Original
Tauopathies - epidemiology
Tauopathies - pathology
Tauopathies - psychology
Title Argyrophilic Grain Disease: Demographics, Clinical, and Neuropathological Features From a Large Autopsy Study
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https://www.ncbi.nlm.nih.gov/pubmed/27283329
https://www.proquest.com/docview/1800401923
https://pubmed.ncbi.nlm.nih.gov/PMC4913431
Volume 75
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