Dietary arachidonic acid-mediated effects on colon inflammation using transcriptome analysis

• Published in: Molecular nutrition & food research Vol. 54; no. S1; pp. S62 - S74
• Main Authors: Knoch, Bianca, Barnett, Matthew P.G, McNabb, Warren C, Zhu, Shuotun, Park, Zaneta A, Khan, Anar, Roy, Nicole C
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley-VCH Verlag 01.05.2010; WILEY-VCH Verlag; WILEY‐VCH Verlag
• Subjects: administration & dosage; Animals; arachidonic acid; Arachidonic Acid - administration & dosage; Arachidonic Acid - pharmacology; chemically induced; Colitis; colon; Colon - physiopathology; deficiency; Diet; Disease Models, Animal; eicosanoids; fibrosis; Gene Deletion; Gene expression; Gene Expression Profiling; Gene Expression Regulation; gene targeting; genes; genetic markers; genetics; Genotype; Humans; IL10 gene-deficient mice; inflammation; Inflammation - genetics; Inflammation - physiopathology; Inflammatory Bowel Diseases; Inflammatory Bowel Diseases - chemically induced; Inflammatory Bowel Diseases - physiopathology; Interleukin-10; Interleukin-10 - deficiency; Interleukin-10 - genetics; Intestinal Mucosa; Intestinal Mucosa - pathology; Intestinal Mucosa - physiopathology; Male; metabolism; Mice; Mice, Inbred C57BL; mucosa; n-6 Polyunsaturated fatty acid; oleic acid; Oligonucleotide Array Sequence Analysis; oxidative stress; pathology; pharmacology; physiopathology; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; Sterol Regulatory Element Binding Protein 1; Sterol Regulatory Element Binding Protein 1 - genetics; transcription factors; transcriptome

Increased levels of n-6 arachidonic acid (AA), a precursor of pro-inflammatory eicosanoids, have been found in the colon mucosa of inflammatory bowel disease patients when compared with healthy subjects. The hypothesis was that dietary AA would aggravate colon inflammation by changing expression of...