Pharmacokinetics of oral nifedipine: relevance of the distribution phase

• Published in: Journal of clinical pharmacology Vol. 29; no. 3; p. 251
• Main Authors: Hoyo-Vadillo, C, Castañeda-Hernández, G, Herrera, J E, Vidal-Gárate, J, Salazar, L A, Moreno-Ramos, A, Chávez, F, Tena, I, Hong, E
• Format: Journal Article
• Language: English
• Published: England 01.03.1989
• Subjects: Administration, Oral; Adult; Chromatography, High Pressure Liquid; Female; Humans; Male; Mexico - ethnology; Nifedipine - administration & dosage; Nifedipine - blood; Nifedipine - pharmacokinetics; Sex Factors; Mexico

Pharmacokinetics of oral Nifedipine was studied in 12 Mexican young healthy volunteers, six men and six women, who received a 10 mg capsule. Plasma levels were determined by a nifedipine specific HPLC assay. Experimental data were fitted and pharmacokinetic parameters were calculated using an open t...