Knockdown XIST alleviates LPS‐induced WI‐38 cell apoptosis and inflammation injury via targeting miR‐370‐3p/TLR4 in acute pneumonia

• Published in: Cell biochemistry and function Vol. 37; no. 5; pp. 348 - 358
• Main Authors: Zhang, Yena, Zhu, Yuyin, Gao, Guosheng, Zhou, Zhiming
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.07.2019; John Wiley and Sons Inc
• Subjects: Acute Disease; Adult; Apoptosis; Apoptosis - drug effects; Cell injury; Cell viability; Cells, Cultured; Cholecystokinin; Cytokines; Drug development; Enzyme-linked immunosorbent assay; Female; Fibroblasts; Flow cytometry; Gene expression; Humans; Inflammation - chemically induced; Inflammation - drug therapy; Inflammation - metabolism; Inflammatory diseases; Inflammatory response; Injuries; JAK/STAT and NF‐κB pathways; Lipopolysaccharides; Lipopolysaccharides - antagonists & inhibitors; Lipopolysaccharides - pharmacology; Lungs; Male; MicroRNAs - analysis; MicroRNAs - antagonists & inhibitors; MicroRNAs - metabolism; miR‐370‐3p; NF-kappa B - metabolism; Pneumonia; Pneumonia - diagnosis; Pneumonia - drug therapy; Pneumonia - metabolism; RNA, Long Noncoding - biosynthesis; RNA, Long Noncoding - genetics; RNA, Small Interfering - pharmacology; Signal Transduction - drug effects; siRNA; TLR4 protein; Toll-Like Receptor 4 - analysis; Toll-Like Receptor 4 - antagonists & inhibitors; Toll-Like Receptor 4 - metabolism; Toll-like receptors; Transcription; Transfection; Western blotting; XIST; miR-370-3p; JAK/STAT and NF-κB pathways; XIST; pneumonia

Pneumonia is an inflammatory disease that occurs in the lungs associated with pathogens or other factors. It has been well established that long noncoding RNA X inactivate‐specific transcript (XIST) is involved in several cancers. The present study focused on the effect and detailed mechanism of XIS...