Knockdown XIST alleviates LPS‐induced WI‐38 cell apoptosis and inflammation injury via targeting miR‐370‐3p/TLR4 in acute pneumonia - Zhang, Yena; Zhu, Yuyin; Gao, Guosheng; Zhou, Zhiming (Cell biochemistry and function, 2019)
Keywords: Acute Disease; Adult; Apoptosis; Apoptosis - drug effects; Cell injury; Cell viability; Cells, Cultured; Cholecystokinin; Cytokines; Drug development; Enzyme-linked immunosorbent assay; Female; Fibroblasts; Flow cytometry; Gene expression; Humans; Inflammation - chemically induced; Inflammation - drug therapy; Inflammation - metabolism; Inflammatory diseases; Inflammatory response; Injuries; JAK/STAT and NF‐κB pathways; Lipopolysaccharides; Lipopolysaccharides - antagonists & inhibitors; Lipopolysaccharides - pharmacology; Lungs; Male; MicroRNAs - analysis; MicroRNAs - antagonists & inhibitors; MicroRNAs - metabolism; miR‐370‐3p; NF-kappa B - metabolism; Pneumonia; Pneumonia - diagnosis; Pneumonia - drug therapy; Pneumonia - metabolism; RNA, Long Noncoding - biosynthesis; RNA, Long Noncoding - genetics; RNA, Small Interfering - pharmacology; Signal Transduction - drug effects; siRNA; TLR4 protein; Toll-Like Receptor 4 - analysis; Toll-Like Receptor 4 - antagonists & inhibitors; Toll-Like Receptor 4 - metabolism; Toll-like receptors; Transcription; Transfection; Western blotting; XIST; miR-370-3p; JAK/STAT and NF-κB pathways; XIST; pneumonia