Prediagnostic Appearance of Thrombospondin Type-1 Domain 7A Autoantibodies in Membranous Nephropathy

• Published in: Kidney360 Vol. 4; no. 2; pp. 217 - 225
• Main Authors: Burbelo, Peter D., Olson, Stephen W., Keller, Jason M., Joshi, Megha, Schwartz, Daniella M., Chuang, Yung-Jen, Lambeau, Gérard, Beck, Laurence H., Waldman, Meryl
• Format: Journal Article
• Language: English
• Published: United States American Society of Nephrology 01.02.2023
• Subjects: Autoantibodies; Glomerular and Tubulointerstitial Diseases; Glomerulonephritis, Membranous - diagnosis; Humans; Original Investigation; Thrombospondins; glomerular and tubulointerstitial diseases; autoantibodies; membranous glomerulonephritis

Key PointsThe entire extracellular domain of thrombospondin type-1 domain 7A (THSD7A) in the luciferase immunoprecipitation system immunoassay was required to detect autoantibodies with high sensitivity in membranous nephropathy (MN).In THSD7A-seropositive MN patients, changes in antibody levels pre...