Highly Site Selective Formal [5+2] and [4+2] Annulations of Isoxazoles with Heterosubstituted Alkynes by Platinum Catalysis: Rapid Access to Functionalized 1,3‐Oxazepines and 2,5‐Dihydropyridines

• Published in: Angewandte Chemie International Edition Vol. 56; no. 2; pp. 605 - 609
• Main Authors: Shen, Wen‐Bo, Xiao, Xin‐Yu, Sun, Qing, Zhou, Bo, Zhu, Xin‐Qi, Yan, Juan‐Zhu, Lu, Xin, Ye, Long‐Wu
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 09.01.2017; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Alkynes; annulation; Catalysis; Chemistry; Chemistry, Multidisciplinary; heterocycles; homogeneous catalysis; Intermediates; Physical Sciences; Platinum; Science & Technology; ynamides; PI-ACID CATALYSIS; PHENOL SYNTHESIS; ENANTIOSELECTIVE GOLD CATALYSIS; MOLECULAR COMPLEXITY; IDENTIFICATION; 3+2 CYCLOADDITION; platinum; annulation; homogeneous catalysis; heterocycles; CARBENES; ynamides; CYCLOISOMERIZATION; CYCLIZATION

Platinum‐catalyzed formal [5+2] and [4+2] annulations of isoxazoles with heterosubstituted alkynes enabled the atom‐economical synthesis of valuable 1,3‐oxazepines and 2,5‐dihydropyridines, respectively. Importantly, this Pt catalysis not only led to unique reactivity dramatically divergent from tha...