Neonatal Growth Restriction Slows Cardiomyocyte Development and Reduces Adult Heart Size

• Published in: Anatomical record (Hoboken, N.J. : 2007) Vol. 301; no. 8; pp. 1398 - 1404
• Main Authors: Knott, Madeline H., Haskell, Sarah E., Strawser, Payton E., Rice, Olivia M., Bonthius, Natalie T., Movva, Vani C., Reinking, Benjamin E., Roghair, Robert D.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.08.2018
• Subjects: Age Factors; Animals; Animals, Newborn; Body Weight - physiology; cardiac development; cardiomyocyte; Cardiomyocytes; Cardiovascular diseases; Cell cycle; Echocardiography; Female; Fibrosis; growth; Heart - growth & development; Immunoreactivity; Infants; left ventricle; Male; Mice; Mice, Inbred C57BL; Morphology; Myocytes, Cardiac; Neonates; Organ Size - physiology; Organogenesis - physiology; prematurity; Ventricle; growth; prematurity; left ventricle; cardiac development; cardiomyocyte

ABSTRACT Prematurity is associated with reduced cardiac dimensions and an increased risk of cardiovascular disease. While prematurity is typically associated with ex utero neonatal growth restriction (GR), the independent effect of neonatal GR on cardiac development has not been established. We test...