Condensed Heterocyclic Compounds: Synthesis and Antiinflammatory Activity of Novel Thiazolo[3,2-a]pyrimidines

• Published in: Archiv der Pharmazie (Weinheim) Vol. 331; no. 6; pp. 201 - 206
• Main Authors: Tozkoparan, Birsen, Ertan, Mevlüt, Krebs, Bernt, Läge, Mechtild, Kelicen, Pelin, Demirdamar, Rümeysa
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag GmbH 01.06.1998; WILEY‐VCH Verlag GmbH; Wiley; Wiley-VCH
• Subjects: 2-a]pyrimidines; 5H-thiazolo; 5H‐thiazolo[3,2‐a]pyrimidines; Animals; Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Antiinflammatory agents; Biological and medical sciences; Bones, joints and connective tissue. Antiinflammatory agents; Carrageenan; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; Edema - chemically induced; Edema - drug therapy; Female; Heterocyclic Compounds - chemical synthesis; Hindlimb; Life Sciences & Biomedicine; Male; Medical sciences; Mice; pharmacology; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Physical Sciences; Pyrimidines - chemical synthesis; Pyrimidines - therapeutic use; Science & Technology; Stomach Ulcer - chemically induced; Stomach Ulcer - drug therapy; Structure-Activity Relationship; synthesis; Thiazoles - chemical synthesis; Thiazoles - therapeutic use; X-ray structure determination; antiinflammatory agents; synthesis; X-ray structure determination; 5H-thiazolo[3,2-a]pyrimidines; pharmacology; CALCIUM-ANTAGONISTS; DERIVATIVES; Sulfur nitrogen heterocycle; Edema; Toxicity; Rodentia; Antiinflammatory agent; Benzene derivatives; Oral administration; Vertebrata; Chemotherapy; Gastroduodenal; Experimental disease; Mammalia; Treatment; Structure activity relation; Mouse; Animal; Bicyclic compound; Ulcer; Chemical synthesis

In this study, thirty six new 2‐benzylidene‐7‐methyl‐3‐oxo‐5‐phenyl‐2,3‐dihydro‐5H‐thiazolo[3,2‐a]pyrimidine‐6‐carboxylic acid methyl esters were synthesized and characterized by spectral, crystallographic, and elemental analysis. The antiinflammatory activity of the compounds was tested by the carr...