Development of a CE‐MS method for the study of riociguat and metabolite M1 in pharmaceutical analysis - Štícha, Martin; Hložek, Tomáš; Bursová, Miroslava; Čabala, Radomír; Jelínek, Ivan (Electrophoresis, 2019)
Keywords: antihypertensive agents; buffers; calibration; Capillary electrophoresis; dissociation; Dissociation constant; Electrolytes; Electrophoresis, Capillary - methods; formates; Fragmentation; Humans; Hypertension; ionic strength; Ions; Limit of Detection; Linear Models; Lithium; lithium acetate; Mass spectrometry; Mass Spectrometry - methods; Metabolites; Parameter estimation; Photometry; Pyrazoles - analysis; Pyrazoles - blood; Pyrazoles - chemistry; Pyrazoles - metabolism; Pyrimidines - analysis; Pyrimidines - blood; Pyrimidines - chemistry; Pyrimidines - metabolism; Reproducibility of Results; Riociguat; Spectrometry; Symmetry; Dissociation constant; Capillary electrophoresis; Mass spectrometry; Riociguat; Fragmentation