Japanese guidelines for the management of palmoplantar keratoderma

• Published in: Journal of dermatology Vol. 48; no. 8; pp. e353 - e367
• Main Authors: Yoneda, Kozo, Kubo, Akiharu, Nomura, Toshifumi, Ishida‐Yamamoto, Akemi, Suga, Yasushi, Akiyama, Masashi, Kanazawa, Nobuo, Hashimoto, Takashi
• Format: Journal Article
• Language: English
• Published: Tokyo Wiley Subscription Services, Inc 01.08.2021
• Subjects: Best practice; diagnostic algorithm; Genetic disorders; Medical diagnosis; Medical treatment; Palmoplantar keratoderma; Pathophysiology; Skin diseases; Systemic diseases; treatment
• ISSN: 0385-2407; 1346-8138
• DOI: 10.1111/1346-8138.15850

Palmoplantar keratoderma (PPK) is a collective term for keratinizing disorders in which the main clinical symptom is hyperkeratosis on the palms and soles. To establish the first Japanese guidelines approved by the Japanese Dermatological Association for the management of PPKs, the Committee for the Management of PPKs was founded as part of the Study Group for Rare Intractable Diseases. These guidelines aim to provide current information for the management of PPKs in Japan. Based on evidence, they summarize the clinical manifestations, pathophysiologies, diagnostic criteria, disease severity determination criteria, treatment, and treatment recommendations. Because of the rarity of PPKs, there are only few clinical studies with a high degree of evidence. Therefore, several parts of these guidelines were established based on the opinions of the committee. To further optimize the guidelines, periodic revision in line with new evidence is necessary.