Urotensin Ⅱ promotes monocyte chemoattractant protein-1 expression in aortic adventitial fibroblasts of rat

• Published in: Chinese medical journal Vol. 127; no. 10; pp. 1907 - 1912
• Main Authors: Zhang, Yonggang, Bao, Shilin, Kuang, Zejian, Ma, Yanjun, Hu, Yanchao, Mao, Yanyan
• Format: Journal Article
• Language: English
• Published: China Department of Cardiology, Second Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong 515041, China 2014; Cardiovascular Laboratory, Centre for Translational Medicine,Shantou University Medical College, Shantou, Guangdong 515041,China%Department of Cardiovascular Diseases, First Affiliated Hospital,Shantou University Medical College, Shantou, Guangdong 515041,China%Department of Cardiology, Second Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong 515041, China
• Subjects: Adventitia - cytology; Animals; Aorta - cytology; Cells, Cultured; Chemokine CCL2 - genetics; Chemokine CCL2 - metabolism; Fibroblasts - drug effects; Fibroblasts - metabolism; Male; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Urotensins - pharmacology; 丝裂原活化蛋白激酶; 主动脉; 加压素; 单核细胞趋化蛋白-1; 外膜; 大鼠; 成纤维细胞; 蛋白激酶抑制剂; urotensin; monocyte chemoattractant protein-1; adventitial fibroblasts; signal transduction

Background Urotensin Ⅱ （Ull）,a potent vasoconstrictive peptide,is able to stimulate phenotypic differentiation of adventitial fibroblasts.This study aimed to determine the effect of UII on monocyte chemoattractant protein-1 （MCP1） expression in rat aortic adventitial fibroblasts,so as to explore pos...