Thyroid Function Variation in the Normal Range, Energy Expenditure, and Body Composition in L-T4–Treated Subjects

• Published in: The journal of clinical endocrinology and metabolism Vol. 102; no. 7; pp. 2533 - 2542
• Main Authors: Samuels, Mary H., Kolobova, Irina, Antosik, Megan, Niederhausen, Meike, Purnell, Jonathan Q., Schuff, Kathryn G.
• Format: Journal Article
• Language: English
• Published: Washington, DC Endocrine Society 01.07.2017; Oxford University Press
• Subjects: Absorptiometry, Photon - methods; Adipose tissue; Adult; Aged; Anthropometry; Body composition; Body Composition - drug effects; Body fat; Body mass index; Body weight; Clinical s; Cross-Sectional Studies; Energy; Energy expenditure; Energy Metabolism - drug effects; Exercise - physiology; Female; Food intake; Humans; Hypothyroidism; Hypothyroidism - diagnosis; Hypothyroidism - drug therapy; Laboratories; Male; Middle Aged; Nutrient deficiency; Oxidation; Physical activity; Reference Values; Severity of Illness Index; Thyroid Function Tests; Thyroid gland; Thyroid hormones; Thyroid-stimulating hormone; Thyroxine; Thyroxine - administration & dosage; Triiodothyronine; Variation; Young Adult

Purpose:It is not clear whether upper limits of the thyrotropin (TSH) reference range should be lowered. This debate can be better informed by investigation of whether variations in thyroid function within the reference range have clinical effects. Thyroid hormone plays a critical role in determinin...