Association between TAP gene polymorphisms and tuberculosis susceptibility in a Han Chinese population in Guangdong

• Published in: Molecular genetics and genomics : MGG Vol. 297; no. 3; pp. 779 - 790
• Main Authors: Luo, Fang, Zou, PinAng, Liao, Yinqian, Luo, Jiaze, Luo, Dan, Hu, Kuan, Zhang, KaiXuan, Wang, BaoGuo
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2022; Springer Nature B.V
• Subjects: Animal Genetics and Genomics; Antigen presentation; Biochemistry; Biomedical and Life Sciences; blood; Case-Control Studies; China; China - epidemiology; Chinese people; Gene Frequency; Gene polymorphism; Genetic analysis; Genetic Predisposition to Disease; genomics; Genotype; genotyping; Haplotypes; Health care; Human Genetics; Humans; humidity; Life Sciences; Microbial Genetics and Genomics; Original; Original Article; peptides; Plant Genetics and Genomics; Polymerase chain reaction; Polymorphism, Single Nucleotide - genetics; Public health; Restriction fragment length polymorphism; risk; Risk groups; Single-nucleotide polymorphism; Susceptibility; Tuberculosis; Tuberculosis - epidemiology; Tuberculosis - genetics; China; Tuberculosis-prone families; Transporter-associated antigen processing; Haplotype; Genetic risk score

Tuberculosis (TB) is an important public health problem. Studies indicated that TAP plays a key role in the presentation and transport of antigenic peptides during anti- M.tb infection. Given the important biological role of the TAP gene involved in anti- M.tb infection, a family-based case–control...