Modafinil enhances extracellular levels of dopamine in the nucleus accumbens and increases wakefulness in rats
Modafinil (MOD) is a wakefulness-promoting drug that improves the alertness levels in narcolepsy; however, the molecular mechanism of action remains to be elucidated. We found that after a single icv injection of MOD (10 μg/5 μl) the extracellular levels of dopamine (DA) and l-DOPA collected from th...
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Published in | Behavioural brain research Vol. 176; no. 2; pp. 353 - 357 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Shannon
Elsevier B.V
25.01.2007
Elsevier Science |
Subjects | |
Online Access | Get full text |
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Summary: | Modafinil (MOD) is a wakefulness-promoting drug that improves the alertness levels in narcolepsy; however, the molecular mechanism of action remains to be elucidated. We found that after a single icv injection of MOD (10
μg/5
μl) the extracellular levels of dopamine (DA) and
l-DOPA collected from the nucleus accumbens were increased and decreased, respectively. Separately, the icv administration of MOD (10
μg/5
μl) to rats enhanced wakefulness (W) whereas diminished sleep during 4
h. Lastly, the alertness induced by MOD was partially antagonized by the sleep-inducing endocannabinoid anandamide (ANA). We conclude that MOD enhances the extracellular levels of DA, promotes W and its effects on sleep are partially blocked by ANA. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0166-4328 1872-7549 |
DOI: | 10.1016/j.bbr.2006.10.016 |