Advanced and Biomedical Applications of Schiff-Base Ligands and Their Metal Complexes: A Review

• Published in: Crystals (Basel) Vol. 12; no. 10; p. 1436
• Main Authors: Soroceanu, Alina, Bargan, Alexandra
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.10.2022
• Subjects: Amino acids; antimicrobial activity; Antimicrobial agents; antioxidant activity; Antioxidants; Biochemistry; Biological activity; Biomedical materials; Carbonyls; Catalysis; catalytic activity; Coordination compounds; Copper; Domains; Fungicides; Gram-positive bacteria; Health aspects; Imines; Interdisciplinary studies; Investigations; Ligands; Materials science; Nitrogen; redox activity; Schiff bases; Schiff-base complexes; siloxane; Single crystals; Romania
• ISSN: 2073-4352; 2073-4352
• DOI: 10.3390/cryst12101436

Because of their importance in a variety of interdisciplinary study domains, Schiff-base ligands have performed a significant role in the evolution of contemporary coordination chemistry. This almost-comprehensive review covers all the aspects and properties of complexes, starting from the Schiff-base ligands. Our work is centered on the eloquent advances that have been developed since 2015, with special consideration to recent developments. Schiff-base ligands and their complexes are adaptable compounds obtained from the condensation of two compounds: a carbonyl with an amino. The correspondent metal complexes have been shown to have antifungal, antibacterial, antioxidant, antiproliferative, and antiviral properties. This review begins with a short introduction to Schiff-base ligands and their metal complexes. It stands out in the recent advancements in the Schiff-base coordination chemistry domain and its future prospects as a potential bioactive core. Additionally, the review contains knowledge about the antioxidant, redox, and catalytic activities of the Schiff-base complexes, with important future applications in the obtaining of new compounds and materials.