Ecklonia cava Ameliorates Cognitive Impairment on Amyloid β-Induced Neurotoxicity by Modulating Oxidative Stress and Synaptic Function in Institute of Cancer Research (ICR) Mice

• Published in: Antioxidants Vol. 13; no. 8; p. 951
• Main Authors: Lee, Hyo Lim, Go, Min Ji, Lee, Han Su, Heo, Ho Jin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 06.08.2024; MDPI
• Subjects: Acids; Alzheimer's disease; antioxidants; Apoptosis; Behavior; Bioactive compounds; Biochemical analysis; Brain research; Brain-derived neurotrophic factor; c-Jun protein; Care and treatment; Cerebral cortex; Chemical properties; cholinergic system; Chromatography; Cognition disorders; Cognitive ability; dieckol; Dietary supplements; Ecklonia cava; Ethanol; Glutathione; Health aspects; High-performance liquid chromatography; JNK protein; Marine algae; marine polyphenol; Mass spectroscopy; Medical research; Membrane potential; Memory; Neurodegenerative diseases; neuroinflammation; Neuropharmacology; Neuroprotection; Neurotoxic agents; Neurotoxicity; NF-κB protein; Oxidative stress; Peptides; Physiological aspects; Physiology; Polyphenols; Reactive oxygen species; Structural proteins; Superoxide dismutase; Synapses; Transcription factors; Water; β-Amyloid; South Korea; United States > US; Germany; Alzheimer’s disease; antioxidants; neuroinflammation; cholinergic system; Ecklonia cava; dieckol; marine polyphenol

This study investigated the neuroprotective effect of 70% ethanol extract of (EE) in amyloid beta (Aβ)-induced cognitive deficit mice. As a result of analyzing the bioactive compounds in EE, nine compounds were identified using ultra-performance liquid chromatography-quadrupole time-of-flight mass s...