Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 1; pp. E71 - E80
• Main Authors: Nishio, Miki, Sugimachi, Keishi, Goto, Hiroki, Wang, Jia, Morikawa, Takumi, Miyachi, Yosuke, Takano, Yusuke, Hikasa, Hiroki, Itoh, Tohru, Suzuki, Satoshi O., Kurihara, Hiroki, Aishima, Shinichi, Leask, Andrew, Sasaki, Takehiko, Nakano, Toru, Nishina, Hiroshi, Nishikawa, Yuji, Sekido, Yoshitaka, Nakao, Kazuwa, Shin-ya, Kazuo, Mimori, Koshi, Suzuki, Akira
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 05.01.2016; National Acad Sciences
• Series: PNAS Plus
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; Animals; Bile Duct Neoplasms - metabolism; Bile Duct Neoplasms - pathology; Biological Sciences; Carcinogenesis - metabolism; Cell Line, Tumor; Cholangiocarcinoma - metabolism; Cholangiocarcinoma - pathology; Connective Tissue Growth Factor - metabolism; Epithelial-Mesenchymal Transition; Genes, Tumor Suppressor; Humans; Hyperplasia - genetics; Hyperplasia - pathology; Intracellular Signaling Peptides and Proteins; Liver - pathology; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Mice; Mice, Knockout; Mice, Nude; Phosphoproteins - genetics; Phosphoproteins - metabolism; PNAS Plus; Protein Kinases - genetics; Protein-Serine-Threonine Kinases - metabolism; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta - metabolism; Signal Transduction; Transcription Factors - metabolism; Transforming Growth Factor beta - metabolism; Xenograft Model Antitumor Assays; TGF-beta; liver cancer; Hippo pathway; MOB1; ivermectin

Mps One Binder Kinase Activator (MOB)1A/1B are core components of the Hippo pathway that coactivate large tumor suppressor homolog (LATS) kinases. Mob1a/1b double deficiency in mouse liver (LMob1DKO) results in hyperplasia of oval cells and immature cholangiocytes accompanied by inflammatory cell in...