Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice - Nishio, Miki; Sugimachi, Keishi; Goto, Hiroki; Wang, Jia; Morikawa, Takumi; Miyachi, Yosuke; Takano, Yusuke; Hikasa, Hiroki; Itoh, Tohru; Suzuki, Satoshi O.; Kurihara, Hiroki; Aishima, Shinichi; et al. (Proceedings of the National Academy of Sciences - PNAS, 2016)
Keywords: Adaptor Proteins, Signal Transducing - metabolism; Animals; Bile Duct Neoplasms - metabolism; Bile Duct Neoplasms - pathology; Biological Sciences; Carcinogenesis - metabolism; Cell Line, Tumor; Cholangiocarcinoma - metabolism; Cholangiocarcinoma - pathology; Connective Tissue Growth Factor - metabolism; Epithelial-Mesenchymal Transition; Genes, Tumor Suppressor; Humans; Hyperplasia - genetics; Hyperplasia - pathology; Intracellular Signaling Peptides and Proteins; Liver - pathology; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Mice; Mice, Knockout; Mice, Nude; Phosphoproteins - genetics; Phosphoproteins - metabolism; PNAS Plus; Protein Kinases - genetics; Protein-Serine-Threonine Kinases - metabolism; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta - metabolism; Signal Transduction; Transcription Factors - metabolism; Transforming Growth Factor beta - metabolism; Xenograft Model Antitumor Assays; TGF-beta; liver cancer; Hippo pathway; MOB1; ivermectin