Correlation between polymorphisms in IGF2/H19 gene locus and epithelial ovarian cancer risk in Chinese population

• Published in: Genomics (San Diego, Calif.) Vol. 112; no. 3; pp. 2510 - 2515
• Main Authors: Zhang, Hai-Bo, Zeng, Ying, Li, Tai-Lin, Wang, Guo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2020
• Subjects: Adult; alleles; animal ovaries; Carcinoma, Ovarian Epithelial - genetics; Carcinoma, Ovarian Epithelial - pathology; Case-Control Studies; China; Epithelial ovarian cancer; epithelium; Female; Gene Frequency; Genetic Loci; genetic models; Genetic Predisposition to Disease; Genotype; H19; Humans; IGF2; Insulin-Like Growth Factor II - genetics; loci; Middle Aged; ovarian neoplasms; Ovarian Neoplasms - genetics; Ovarian Neoplasms - pathology; patients; Polymorphism; Polymorphism, Single Nucleotide; risk; Risk Factors; RNA, Long Noncoding - genetics; single nucleotide polymorphism; China; IGF2; H19; Genotype; Epithelial ovarian cancer; Polymorphism

To investigate the association between SNPs in human IGF2/H19 gene locus and epithelial ovarian cancer (EOC) risk, we performed a case-control study in 422 individuals (219 EOC patients and 203 cancer-free controls). Four SNPs (rs2525885, rs2839698, rs3741206, rs3741219) were found to be related wit...