Association of environmental benzo[a]pyrene exposure and DNA methylation alterations in hepatocellular carcinoma: A Chinese case–control study

• Published in: The Science of the total environment Vol. 541; pp. 1243 - 1252
• Main Authors: Tian, Meiping, Zhao, Benhua, Zhang, Jie, Martin, Francis L., Huang, Qingyu, Liu, Liangpo, Shen, Heqing
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.01.2016
• Subjects: Adult; alcohol drinking; Alterations; B[a]P; benzo(a)pyrene; Benzo(a)pyrene - toxicity; blood sampling; blood serum; Carcinoma, Hepatocellular - epidemiology; Carcinoma, Hepatocellular - metabolism; Case control study; Case-Control Studies; China; China - epidemiology; correlation; cytotoxicity; Deoxyribonucleic acid; DNA Methylation; Ecological risk assessment; Environmental Exposure - statistics & numerical data; environmental factors; Environmental Pollutants - toxicity; Epidemiology; Epigenetic; epigenetics; Female; Genes; glutathione transferase; GSTP; hepatitis B; Hepatitis B virus; Hepatitis C virus; Hepatocellular carcinoma; hepatocytes; hepatoma; Humans; Liver Neoplasms - epidemiology; Liver Neoplasms - metabolism; Male; Mathematical models; melting; Methylation; Middle Aged; patients; promoter regions; protective effect; Risk analysis; risk factors; tumor suppressor genes; viruses; volunteers; China; China, People's Rep; DNA methylation; GSTP; Hepatocellular carcinoma; Case control study; Epigenetic; B[a]P

Epidemiological studies implicate environmental risk factors and epigenetic alterations in the multistage process of hepatocellular carcinoma (HCC) development. However, associations between environmental factors and DNA methylation of tumour suppressor genes (TSGs) in HCC development remain ambiguo...