Prognostic impact of intra tumoral HPV-16 viral load in oropharyngeal squamous cell carcinomas

• Published in: Oral oncology Vol. 159; p. 107082
• Main Authors: Villarmé, Agathe, Ebran, Nathalie, Pace-Loscos, Tanguy, Schiappa, Renaud, Mignot, Audrey, Bozec, Alexandre, Sudaka-Bahadoran, Anne, Saada-Bouzid, Esma, Culié, Dorian
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2024
• Subjects: Aged; Aged, 80 and over; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - virology; droplet digital PCR; Female; Head and Neck Squamous Cell Carcinoma; Hematology, Oncology, and Palliative Medicine; HPV load; Human Papillomavirus; Human papillomavirus 16 - genetics; Human papillomavirus 16 - isolation & purification; Humans; Male; Middle Aged; Oropharyngeal Neoplasms - mortality; Oropharyngeal Neoplasms - pathology; Oropharyngeal Neoplasms - virology; Oropharynx cancer; Otolaryngology; Papillomavirus Infections - complications; Papillomavirus Infections - virology; Prognosis; Retrospective Studies; Squamous Cell Carcinoma of Head and Neck - mortality; Squamous Cell Carcinoma of Head and Neck - pathology; Squamous Cell Carcinoma of Head and Neck - virology; Viral Load; Oropharynx cancer; Human Papillomavirus; Head and Neck Squamous Cell Carcinoma; HPV load; droplet digital PCR

•HPV-related oropharyngeal squamous cell carcinomas have a more favorable prognosis than those linked to tobacco.•Oropharyngeal cancers both linked to tobacco and HPV have an intermediate prognosis.•In a series of 192 patients, we highlight an independent prognostic role of HPV viral load.•Subject t...