Anti-inflammatory and antioxidant effects of Jeevaneeya Rasayana: an ayurvedic polyherbal formulation on acute and chronic models of inflammation

• Published in: Immunopharmacology and immunotoxicology Vol. 32; no. 4; pp. 569 - 575
• Main Authors: Shyni, G.L., Ratheesh, M., Sindhu, G., Helen, A.
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 01.12.2010; Taylor & Francis
• Subjects: Animals; Anti-inflammatory; Anti-Inflammatory Agents, Non-Steroidal - chemistry; Anti-Inflammatory Agents, Non-Steroidal - isolation & purification; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Anti-Inflammatory Agents, Non-Steroidal - toxicity; antioxidant; Antioxidants - chemistry; Antioxidants - isolation & purification; Antioxidants - therapeutic use; Antioxidants - toxicity; Arachidonate 5-Lipoxygenase - metabolism; arthritis; Arthritis - blood; Arthritis - chemically induced; Arthritis - drug therapy; Arthritis - metabolism; C-Reactive Protein - metabolism; Carrageenan - pharmacology; Cartilage, Articular - drug effects; Cartilage, Articular - metabolism; Catalase - metabolism; Ceruloplasmin - metabolism; Chromatography, High Pressure Liquid; Complex Mixtures - chemistry; Complex Mixtures - isolation & purification; Complex Mixtures - therapeutic use; Complex Mixtures - toxicity; cyclooxygenase; Diclofenac - therapeutic use; Edema - chemically induced; Edema - pathology; Edema - prevention & control; Foot - pathology; Freund's Adjuvant - pharmacology; Glutathione - blood; Glutathione Peroxidase - metabolism; Hindlimb - metabolism; Hindlimb - pathology; Indomethacin - therapeutic use; Inflammation - blood; Inflammation - chemically induced; Inflammation - drug therapy; Inflammation - metabolism; Inflammation - prevention & control; Lethal Dose 50; lipoxygenase; Male; Medicine, Ayurvedic; Monocytes - drug effects; Monocytes - metabolism; Peroxidase - metabolism; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - therapeutic use; Plant Extracts - toxicity; Prostaglandin-Endoperoxide Synthases - metabolism; Rats; Rats, Wistar; Superoxide Dismutase - metabolism; Thiobarbituric Acid Reactive Substances - metabolism; Vitamins - blood

The present study was aimed to establish the efficacy of Jeevaneeya Rasayana (JR), an ayurvedic polyherbal formulation, in adjuvant-induced arthritic (AIA) rat model with reference to mediators of inflammation. The methanolic (MJR), ethanolic (EJR), and water extracts (WJR) of JR were prepared and t...