Mitochondrial COX3 and tRNA Gene Variants Associated with Risk and Prognosis of Idiopathic Pulmonary Fibrosis

• Published in: International journal of molecular sciences Vol. 26; no. 3; p. 1378
• Main Authors: Lee, Li-Na, Jan, I-Shiow, Chou, Wen-Ru, Liu, Wei-Lun, Kuo, Yen-Liang, Chang, Chih-Yueh, Chang, Hsiu-Ching, Liu, Jia-Luen, Hsu, Chia-Lin, Lin, Chia-Nan, Chao, Ke-Yun, Tseng, Chi-Wei, Lee, I-Hsien, Wang, Jann-Tay, Wang, Jann-Yuan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2025; MDPI
• Subjects: Aged; Aged, 80 and over; Apoptosis; Case-Control Studies; Disease; DNA, Mitochondrial - genetics; Electron Transport Complex IV - genetics; Enzymes; Female; Fibroblasts; Genes; Genetic aspects; Genetic Predisposition to Disease; Genomes; Genomics; Growth factors; Humans; Idiopathic Pulmonary Fibrosis - genetics; Idiopathic Pulmonary Fibrosis - mortality; Idiopathic Pulmonary Fibrosis - pathology; Leukocytes - metabolism; Male; Medical prognosis; Middle Aged; Mitochondria; Mitochondria - genetics; Mitochondrial DNA; Mortality; Newfoundland and Labrador; Patients; Prognosis; Proteins; Pulmonary fibrosis; Risk Factors; RNA, Transfer - genetics; Survival analysis; Taiwan; Transfer RNA; Taiwan; Newfoundland and Labrador; nonsynonymous variant; cytochrome c oxidase subunit 3 (COX3); idiopathic pulmonary fibrosis (IPF); tRNA variant; mitochondrial DNA (mtDNA)

Idiopathic pulmonary fibrosis (IPF) has been associated with mitochondrial dysfunction. We investigated whether mitochondrial DNA variants in peripheral blood leukocytes (PBLs), which affect proteins of the respiratory chain and mitochondrial function, could be associated with an increased risk and...