Inflammatory Processes Triggered by Helicobacter pylori Infection Cause Aberrant DNA Methylation in Gastric Epithelial Cells

• Published in: Cancer research (Chicago, Ill.) Vol. 70; no. 4; pp. 1430 - 1440
• Main Authors: Niwa, Tohru, Tsukamoto, Tetsuya, Toyoda, Takeshi, Mori, Akiko, Tanaka, Harunari, Maekita, Takao, Ichinose, Masao, Tatematsu, Masae, Ushijima, Toshikazu
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.02.2010
• Subjects: Adult; Aged; Animals; Antineoplastic agents; Bacterial diseases; Bacterial diseases of the digestive system and abdomen; Biological and medical sciences; Carcinoma - etiology; Carcinoma - genetics; Cells, Cultured; DNA Methylation - drug effects; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Female; Gastritis - etiology; Gastritis - genetics; Gastritis - pathology; Gerbillinae; Helicobacter Infections - complications; Helicobacter Infections - genetics; Helicobacter Infections - metabolism; Helicobacter Infections - pathology; Helicobacter pylori - physiology; Human bacterial diseases; Humans; Infectious diseases; Inflammation - genetics; Inflammation - metabolism; Inflammation - pathology; Inflammation Mediators - metabolism; Inflammation Mediators - pharmacology; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Risk Factors; Stomach - metabolism; Stomach - pathology; Stomach Neoplasms - etiology; Stomach Neoplasms - genetics; Tumors; Young Adult; Infection; Stomach; Spirillales; Helicobacter pylori; Digestive system; DNA; Spirillaceae; Bacteriosis; Bacteria; Epithelial cell; Inflammation; Methylation

Altered patterns of DNA methylation associated with Helicobacter pylori (HP) infection of gastric epithelial cells are thought to contribute to gastric cancer risk. However, it is unclear whether this increased risk reflects an infection-associated inflammatory response or the infection itself. In t...