Prognostic nutrition index affects the prognosis of patients undergoing trimodality therapy for locally advanced non-small cell lung cancer

• Published in: Surgery today (Tokyo, Japan) Vol. 50; no. 12; pp. 1610 - 1618
• Main Authors: Soh, Junichi, Suzawa, Ken, Shien, Kazuhiko, Otani, Shinji, Yamamoto, Hiromasa, Okazaki, Mikio, Sugimoto, Seiichiro, Katsui, Kuniaki, Yamane, Masaomi, Kiura, Katsuyuki, Kanazawa, Susumu, Toyooka, Shinichi
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.12.2020
• Subjects: Adult; Aged; Carcinoma, Non-Small-Cell Lung - mortality; Carcinoma, Non-Small-Cell Lung - pathology; Carcinoma, Non-Small-Cell Lung - physiopathology; Carcinoma, Non-Small-Cell Lung - therapy; Combined Modality Therapy; Female; Humans; Induction Chemotherapy; Lung Neoplasms - mortality; Lung Neoplasms - pathology; Lung Neoplasms - physiopathology; Lung Neoplasms - therapy; Male; Medicine; Medicine & Public Health; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Nutrition Assessment; Nutrition Therapy; Nutritional Physiological Phenomena - physiology; Original Article; Pneumonectomy; Prognosis; Surgery; Surgical Oncology; Survival Rate; Treatment Outcome; Nutrition; Induction chemoradiotherapy followed by surgery; Prognosis
• DOI: 10.1007/s00595-020-02067-7
• ISSN: 0941-1291; 1436-2813

Purpose Trimodality therapy, comprised of induction chemoradiotherapy (iCRT) followed by surgery, is a highly invasive treatment option for locally advanced non-small cell lung cancers (LA-NSCLCs; defined as a heterogenous disease). We conducted this study to investigate the prognostic nutritional index (PNI) of LA-NSCLC patients undergoing trimodality therapy, which has not been studied in detail before. Methods The subjects of this retrospective study were 127 patients who underwent trimodality therapy between 1999 and 2016. We measured the PNI at three points: before iCRT (pre-iCRT), before the operation, and after the operation. Results PNIs decreased significantly as treatment progressed. Patients with clinical T3/4 (cT3/4) disease had a significantly lower PNI than those with cT1/2 disease, but the extent of lymph-node metastasis did not affect the PNI at any point. Using the cut-off values of receiver-operating curve analyses, multivariable analyses revealed that a high PNI pre-iCRT correlated significantly with a better survival of LA-NSCLC patients, especially those with cT3/4 disease (hazard ratio 3.84; 95% confidential interval 1.34–12.5, P  = 0.012). Conclusions Measuring the PNI before trimodality therapy is important for predicting the clinical outcome of patients with LA-NSCLC, with differing predictive ability according to the disease extent. Perioperative intensive nutritional intervention must be considered for patients who undergo trimodality therapy for LA-NSCLC.