Glial Cell Line-Derived Neurotrophic Factor Induces Barrier Function of Endothelial Cells Forming the Blood–Brain Barrier

• Published in: Biochemical and biophysical research communications Vol. 261; no. 1; pp. 108 - 112
• Main Authors: Igarashi, Yo, Utsumi, Hiroyuki, Chiba, Hideki, Yamada-Sasamori, Yumiko, Tobioka, Hirotoshi, Kamimura, Yasuhiro, Furuuchi, Ken, Kokai, Yasuo, Nakagawa, Takashi, Mori, Michio, Sawada, Norimasa
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 22.07.1999
• Subjects: Animals; Blood-Brain Barrier - drug effects; Cell Membrane - chemistry; Cell Membrane - drug effects; Cell Membrane Permeability - drug effects; Cells, Cultured; Cerebral Cortex - blood supply; Cerebral Cortex - chemistry; Cerebral Cortex - cytology; Cyclic AMP - pharmacology; Dose-Response Relationship, Drug; Drosophila Proteins; Electric Impedance; Endothelium, Vascular - chemistry; Endothelium, Vascular - cytology; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiology; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Immunohistochemistry; Nerve Growth Factors; Nerve Tissue Proteins - pharmacology; Proto-Oncogene Proteins - analysis; Proto-Oncogene Proteins c-ret; Rats; Receptor Protein-Tyrosine Kinases - analysis; Swine; Tight Junctions - drug effects; Tight Junctions - physiology; Time Factors

Since a deep involvement of astrocytes, a kind of glial cells, in differentiation of the blood–brain barrier (BBB) has been suggested, we examined the relation of glial cell line-derived neurotrophic factor (GDNF) to the BBB. First, immunohistochemical examination of the cerebral cortex of rats reve...