Familial Creutzfeldt-Jakob Disease with V180I Mutation
Creutzfeldt-Jakob disease (CJD) is an uncommon neurodegenerative disorder with an incidence of 1 per 1000,000 per year typically characterized by rapidly progressive dementia, ataxia, myoclonus and behavioral changes. Genetic prion diseases, which develop due to a mutations in the prion protein gene...
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| Published in | Journal of Korean medical science Vol. 25; no. 7; pp. 1097 - 1100 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
The Korean Academy of Medical Sciences
01.07.2010
대한의학회 |
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| Online Access | Get full text |
| ISSN | 1011-8934 1598-6357 1598-6357 |
| DOI | 10.3346/jkms.2010.25.7.1097 |
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| Abstract | Creutzfeldt-Jakob disease (CJD) is an uncommon neurodegenerative disorder with an incidence of 1 per 1000,000 per year typically characterized by rapidly progressive dementia, ataxia, myoclonus and behavioral changes. Genetic prion diseases, which develop due to a mutations in the prion protein gene (PRNP), account for an estimated 10 to 15% of all CJD cases. We report a 75-yr-old woman with familial CJD carrying a V180I mutation which features late onset, slow progression, no periodic sharp wave complexes on electroencephalography, and extensive cortical ribboning with spared the cerebellum and the medial occipital lobes posterior to the parieto-occipital sulcus on MRI. To our knowledge, this is the first documented case of a point mutation at codon 180 in South Korea. |
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| AbstractList | Creutzfeldt-Jakob disease (CJD) is an uncommon neurodegenerative disorder with an incidence of 1 per 1000,000 per year typically characterized by rapidly progressive dementia, ataxia, myoclonus and behavioral changes. Genetic prion diseases, which develop due to a mutations in the prion protein gene (PRNP), account for an estimated 10 to 15% of all CJD cases. We report a 75-yr-old woman with familial CJD carrying a V180I mutation which features late onset, slow progression, no periodic sharp wave complexes on electroencephalography, and extensive cortical ribboning with spared the cerebellum and the medial occipital lobes posterior to the parieto-occipital sulcus on MRI. To our knowledge, this is the first documented case of a point mutation at codon 180 in South Korea. Creutzfeldt-Jakob disease (CJD) is an uncommon neurodegenerative disorder with an incidence of 1 per 1000,000 per year typically characterized by rapidly progressive dementia, ataxia, myoclonus and behavioral changes. Genetic prion diseases, which develop due to a mutations in the prion protein gene (PRNP), account for an estimated 10 to 15% of all CJD cases. We report a 75-yr-old woman with familial CJD carrying a V180I mutation which features late onset, slow progression, no periodic sharp wave complexes on electroencephalography, and extensive cortical ribboning with spared the cerebellum and the medial occipital lobes posterior to the parieto-occipital sulcus on MRI. To our knowledge, this is the first documented case of a point mutation at codon 180 in South Korea. KCI Citation Count: 4 Creutzfeldt-Jakob disease (CJD) is an uncommon neurodegenerative disorder with an incidence of 1 per 1000,000 per year typically characterized by rapidly progressive dementia, ataxia, myoclonus and behavioral changes. Genetic prion diseases, which develop due to a mutations in the prion protein gene (PRNP), account for an estimated 10 to 15% of all CJD cases. We report a 75-yr-old woman with familial CJD carrying a V180I mutation which features late onset, slow progression, no periodic sharp wave complexes on electroencephalography, and extensive cortical ribboning with spared the cerebellum and the medial occipital lobes posterior to the parieto-occipital sulcus on MRI. To our knowledge, this is the first documented case of a point mutation at codon 180 in South Korea.Creutzfeldt-Jakob disease (CJD) is an uncommon neurodegenerative disorder with an incidence of 1 per 1000,000 per year typically characterized by rapidly progressive dementia, ataxia, myoclonus and behavioral changes. Genetic prion diseases, which develop due to a mutations in the prion protein gene (PRNP), account for an estimated 10 to 15% of all CJD cases. We report a 75-yr-old woman with familial CJD carrying a V180I mutation which features late onset, slow progression, no periodic sharp wave complexes on electroencephalography, and extensive cortical ribboning with spared the cerebellum and the medial occipital lobes posterior to the parieto-occipital sulcus on MRI. To our knowledge, this is the first documented case of a point mutation at codon 180 in South Korea. |
| Author | Cho, Han-Jeong Yang, Tae-Il Ahn, Bo-Young Jeong, Byung-Hoon Geschwind, Michael D. Kim, Eun-Joo Jung, Dae-Soo Kim, Yong-Sun |
| AuthorAffiliation | 3 Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 2 Ilsong Institute of Life Science, Hallym University, Anyang, Korea 4 Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, USA 1 Department of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea |
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| Cites_doi | 10.1212/01.wnl.0000290370.14036.69 10.1002/ana.20261 10.1212/01.WNL.0000106954.54011.80 10.1212/01.WNL.0000134555.59460.5D 10.1016/j.neulet.2006.08.008 10.1212/01.wnl.0000196440.00297.67 10.1034/j.1600-0463.2002.100111.x 10.1093/brain/awl159 10.1016/S0140-6736(99)01342-2 |
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| References | Geschwind (10.3346/jkms.2010.25.7.1097_ref10) 2007; 69 Heinemann (10.3346/jkms.2010.25.7.1097_ref2) 2008; 14 Shiga (10.3346/jkms.2010.25.7.1097_ref6) 2004; 63 Alperovitch (10.3346/jkms.2010.25.7.1097_ref15) 1999; 353 Kong (10.3346/jkms.2010.25.7.1097_ref3) 2004 Rabinovici (10.3346/jkms.2010.25.7.1097_ref1) 2006; 66 Chasseigneaux (10.3346/jkms.2010.25.7.1097_ref12) 2006; 408 Yamada (10.3346/jkms.2010.25.7.1097_ref11) 2007; 47 Zerr (10.3346/jkms.2010.25.7.1097_ref4) 2002; 110 Nixon (10.3346/jkms.2010.25.7.1097_ref13) 2000; 10 10.3346/jkms.2010.25.7.1097_ref5 Jin (10.3346/jkms.2010.25.7.1097_ref14) 2004; 62 Young (10.3346/jkms.2010.25.7.1097_ref7) 2005; 26 Steinhoff (10.3346/jkms.2010.25.7.1097_ref9) 2004; 56 Collins (10.3346/jkms.2010.25.7.1097_ref8) 2006; 129 16434680 - Neurology. 2006 Jan 24;66(2):286-7 17029785 - Neurosci Lett. 2006 Nov 20;408(3):165-9 15304574 - Neurology. 2004 Aug 10;63(3):443-9 12064260 - APMIS. 2002 Jan;110(1):88-98 14872044 - Neurology. 2004 Feb 10;62(3):502-5 16816392 - Brain. 2006 Sep;129(Pt 9):2278-87 17984457 - Neurology. 2007 Nov 6;69(19):1881-7 10335789 - Lancet. 1999 May 15;353(9165):1673-4 18443555 - Med Sci Monit. 2008 May;14(5):CS41-43 15956529 - AJNR Am J Neuroradiol. 2005 Jun-Jul;26(6):1551-62 18210803 - Rinsho Shinkeigaku. 2007 Nov;47(11):805-8 15449324 - Ann Neurol. 2004 Nov;56(5):702-8 |
| References_xml | – volume-title: Emerging and other communicable diseases, surveillance and control ident: 10.3346/jkms.2010.25.7.1097_ref5 – volume: 69 start-page: 1881 year: 2007 ident: 10.3346/jkms.2010.25.7.1097_ref10 publication-title: Neurology doi: 10.1212/01.wnl.0000290370.14036.69 – volume: 56 start-page: 702 year: 2004 ident: 10.3346/jkms.2010.25.7.1097_ref9 publication-title: Ann Neurol doi: 10.1002/ana.20261 – start-page: 673 volume-title: Prion Biology and Disease year: 2004 ident: 10.3346/jkms.2010.25.7.1097_ref3 – volume: 10 start-page: 670 year: 2000 ident: 10.3346/jkms.2010.25.7.1097_ref13 publication-title: Brain Pathology – volume: 14 start-page: CS41 year: 2008 ident: 10.3346/jkms.2010.25.7.1097_ref2 publication-title: Med Sci Monit – volume: 62 start-page: 502 year: 2004 ident: 10.3346/jkms.2010.25.7.1097_ref14 publication-title: Neurology doi: 10.1212/01.WNL.0000106954.54011.80 – volume: 63 start-page: 443 year: 2004 ident: 10.3346/jkms.2010.25.7.1097_ref6 publication-title: Neurology doi: 10.1212/01.WNL.0000134555.59460.5D – volume: 26 start-page: 1551 year: 2005 ident: 10.3346/jkms.2010.25.7.1097_ref7 publication-title: AJNR Am J Neuroradiol – volume: 408 start-page: 165 year: 2006 ident: 10.3346/jkms.2010.25.7.1097_ref12 publication-title: Neurosci Lett doi: 10.1016/j.neulet.2006.08.008 – volume: 66 start-page: 286 year: 2006 ident: 10.3346/jkms.2010.25.7.1097_ref1 publication-title: Neurology doi: 10.1212/01.wnl.0000196440.00297.67 – volume: 110 start-page: 88 year: 2002 ident: 10.3346/jkms.2010.25.7.1097_ref4 publication-title: APMIS doi: 10.1034/j.1600-0463.2002.100111.x – volume: 129 start-page: 2278 year: 2006 ident: 10.3346/jkms.2010.25.7.1097_ref8 publication-title: Brain doi: 10.1093/brain/awl159 – volume: 47 start-page: 805 year: 2007 ident: 10.3346/jkms.2010.25.7.1097_ref11 publication-title: Rinsho Shinkeigaku – volume: 353 start-page: 1673 year: 1999 ident: 10.3346/jkms.2010.25.7.1097_ref15 publication-title: Lancet doi: 10.1016/S0140-6736(99)01342-2 – reference: 14872044 - Neurology. 2004 Feb 10;62(3):502-5 – reference: 18443555 - Med Sci Monit. 2008 May;14(5):CS41-43 – reference: 15956529 - AJNR Am J Neuroradiol. 2005 Jun-Jul;26(6):1551-62 – reference: 12064260 - APMIS. 2002 Jan;110(1):88-98 – reference: 17029785 - Neurosci Lett. 2006 Nov 20;408(3):165-9 – reference: 15449324 - Ann Neurol. 2004 Nov;56(5):702-8 – reference: 17984457 - Neurology. 2007 Nov 6;69(19):1881-7 – reference: 10335789 - Lancet. 1999 May 15;353(9165):1673-4 – reference: 15304574 - Neurology. 2004 Aug 10;63(3):443-9 – reference: 16816392 - Brain. 2006 Sep;129(Pt 9):2278-87 – reference: 18210803 - Rinsho Shinkeigaku. 2007 Nov;47(11):805-8 – reference: 16434680 - Neurology. 2006 Jan 24;66(2):286-7 |
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| SubjectTerms | Aged Base Sequence Case Report Codon Creutzfeldt-Jakob Syndrome - genetics Creutzfeldt-Jakob Syndrome - physiopathology DNA Mutational Analysis Female Humans Neuropsychological Tests Point Mutation Prions - genetics Republic of Korea 의학일반 |
| Title | Familial Creutzfeldt-Jakob Disease with V180I Mutation |
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