β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage

• Published in: Alzheimer's research & therapy Vol. 6; no. 5-8; p. 75
• Main Authors: Portelius, Erik, Dean, Robert A, Andreasson, Ulf, Mattsson, Niklas, Westerlund, Anni, Olsson, Maria, Demattos, Ronald Bradley, Racke, Margaret M, Zetterberg, Henrik, May, Patrick C, Blennow, Kaj
• Format: Journal Article
• Language: English
• Published: England BioMed Central 01.01.2014
• Subjects: Neurosciences; Neurovetenskaper

The β-secretase enzyme, β-site amyloid precursor protein-cleaving enzyme 1 (BACE1), cleaves amyloid precursor protein (APP) in the first step in β-amyloid (Aβ) peptide production. Thus, BACE1 is a key target for candidate disease-modifying treatment of Alzheimer's disease. In a previous explora...