Scaling of prediction error does not confirm chaotic dynamics underlying irregular firing using interspike intervals from midbrain dopamine neurons

• Published in: Neuroscience Vol. 129; no. 2; pp. 491 - 502
• Main Authors: Canavier, C.C., Perla, S.R., Shepard, P.D.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 2004; Elsevier
• Subjects: Algorithms; Animals; Biological and medical sciences; Dopamine - physiology; Electrophysiology; firing pattern; Forecasting; Fundamental and applied biological sciences. Psychology; Membrane Potentials - physiology; Mesencephalon - cytology; Mesencephalon - physiology; Neurons - physiology; noise; Nonlinear Dynamics; nonlinear forecasting; pacemaker; Potassium Channels, Calcium-Activated - drug effects; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Small-Conductance Calcium-Activated Potassium Channels; Stochastic Processes; substantia nigra; temporal coding; Vertebrates: nervous system and sense organs; substantia nigra; pacemaker; r s; nonlinear forecasting; r; CV; temporal coding; SDF; IPSC; TISEAN; noise; SK; firing pattern; ISI; Noise; Central nervous system; Discharge pattern; Electrophysiology; Midbrain; Encephalon; Locus niger; Pacemaker; Dopaminergic neuron

Dopamine neurons in the substantia nigra pars compacta often fire in an irregular, single spike mode in vivo, and a similar firing pattern can be observed in vitro when small conductance calcium-activated potassium channel blockers are applied to the bath. It is not clear whether the irregular firin...