Bovine lactoferricin B induces apoptosis of human gastric cancer cell line AGS by inhibition of autophagy at a late stage

• Published in: Journal of dairy science Vol. 96; no. 12; pp. 7511 - 7520
• Main Authors: Pan, W.-R., Chen, P.-W., Chen, Y.-L. S., Hsu, H.-C., Lin, C.-C., Chen, W.-J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2013
• Subjects: adverse effects; Animals; antimicrobial cationic peptides; Antimicrobial Cationic Peptides - pharmacology; apoptosis; Apoptosis - drug effects; Apoptosis Regulatory Proteins - metabolism; autophagy; Autophagy - drug effects; Beclin-1; bovine lactoferricin B; caspases; Caspases - metabolism; Cattle; cell cycle; cell growth; Cell Line, Tumor - drug effects; cell membranes; Cell Proliferation - drug effects; Cell Survival - drug effects; cell viability; cytotoxicity; Drug Evaluation, Preclinical; drug resistance; Flow Cytometry; gastric cancer; Humans; inhibitory concentration 50; lactoferrin; Lactoferrin - pharmacology; Membrane Proteins - metabolism; mortality; Poly(ADP-ribose) Polymerases - metabolism; prognosis; stomach neoplasms; Stomach Neoplasms - drug therapy; Western blotting; apoptosis; autophagy; gastric cancer; bovine lactoferricin B

Gastric cancer is one of the most common malignant cancers, with poor prognosis and high mortality rates worldwide. Therefore, development of an effective therapeutic method without side effects is an urgent need. It has been reported that cationic antimicrobial peptides can selectively bind to nega...