Smooth muscle relaxant effects of propofol and ketamine in isolated guinea-pig trachea

• Published in: European journal of pharmacology Vol. 238; no. 1; pp. 75 - 80
• Main Authors: Pedersen, Charles M., Thirstrup, Steffen, Nielsen-Kudsk, Jens Erik
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 06.07.1993; Elsevier
• Subjects: Anaesthetics; Anesthetics. Neuromuscular blocking agents; Animals; Asthma; Biological and medical sciences; Carbachol - pharmacology; Dinoprost - pharmacology; Dose-Response Relationship, Drug; Female; Guinea Pigs; Histamine - pharmacology; In Vitro Techniques; Ketamine; Ketamine - pharmacology; Male; Medical sciences; Muscle Relaxation - drug effects; Muscle, Smooth - drug effects; Muscle, Smooth - physiology; Neuropharmacology; Pharmacology. Drug treatments; Potassium - pharmacology; Propofol; Propofol - pharmacology; Smooth muscle; Trachea; Trachea - drug effects; Trachea - physiology; Smooth muscle; Ketamine; Propofol; Trachea; Asthma; Anaesthetics; Bronchodilation; Intravenous administration; Rodentia; In vitro; Muscular relaxation; Respiratory tract; Vertebrata; Mammalia; Guinea pig; General anesthetic; Animal; Comparative study

The effects of anesthetics on airway smooth muscle tone are important in the management of patients with asthma. In the present study we evaluated the effect of propofol and ketamine on isolated guinea-pig tracheal preparations mounted for recording isometric contractile force. In a concentration-de...