Progesterone Receptor Membrane Component-1 Regulates the Development and Cisplatin Sensitivity of Human Ovarian Tumors in Athymic Nude Mice

• Published in: Endocrinology (Philadelphia) Vol. 150; no. 11; pp. 4846 - 4854
• Main Authors: Peluso, John J, Gawkowska, Anna, Liu, Xiufang, Shioda, Toshi, Pru, James K
• Format: Journal Article
• Language: English
• Published: United States Endocrine Society 01.11.2009
• Subjects: Animals; Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Cell Line, Tumor; Cisplatin - pharmacology; Female; Gene Expression; Humans; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mice, Nude; Neoplasm Transplantation; Neoplastic Processes; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; Ovarian Neoplasms - physiopathology; Receptors, Progesterone - genetics; Receptors, Progesterone - metabolism; Tumor Burden

To determine whether progesterone receptor membrane component 1 (PGRMC1) regulates the development and cisplatin (CDDP)-sensitivity of human ovarian tumors, PGRMC1 was depleted from a human ovarian cancer cell line, dsRed-SKOV-3 cells, using a short hairpin RNA knockdown approach. Compared with pare...