Caveolin-1 Expression and Cavin Stability Regulate Caveolae Dynamics in Adipocyte Lipid Store Fluctuation

• Published in: Diabetes (New York, N.Y.) Vol. 63; no. 12; pp. 4032 - 4044
• Main Authors: Briand, Nolwenn, Prado, Cécilia, Mabilleau, Guillaume, Lasnier, Françoise, Le Lièpvre, Xavier, Covington, Jeffrey D., Ravussin, Eric, Le Lay, Soazig, Dugail, Isabelle
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.12.2014
• Subjects: 3T3-L1 Cells; Adipocytes - metabolism; Adult; Animals; Caveolae - metabolism; Caveolin 1 - genetics; Caveolin 1 - metabolism; Cells; Diabetes; Female; Glucose; Humans; Life Sciences; Lipid Metabolism; Lipids; Male; Membrane Proteins - genetics; Membrane Proteins - metabolism; Metabolism; Mice; Mice, Nude; Proteins; RNA, Messenger - analysis; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Rodents; Young Adult; RNA; Humans; Adipocytes/metabolism; Caveolin 1/metabolism; Membrane Proteins/genetics; Lipid Metabolism; Male; RNA-Binding Proteins/genetics; Messenger/analysis; 3T3-L1 Cells; Nude; RNA-Binding Proteins/metabolism; Young Adult; Animals; Membrane Proteins/metabolism; Caveolin 1/genetics; Adult; Female; Mice; Caveolae/metabolism
• ISSN: 0012-1797; 1939-327X; 1939-327X
• DOI: 10.2337/db13-1961

Adipocytes specialized in the storage of energy as fat are among the most caveolae-enriched cell types. Loss of caveolae produces lipodystrophic diabetes in humans, which cannot be reversed by endothelial rescue of caveolin expression in mice, indicating major importance of adipocyte caveolae. Howev...