Antiviral activity of favipiravir (T-705) against mammalian and avian bornaviruses

• Published in: Antiviral research Vol. 143; pp. 237 - 245
• Main Authors: Tokunaga, Tomoya, Yamamoto, Yusuke, Sakai, Madoka, Tomonaga, Keizo, Honda, Tomoyuki
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2017
• Subjects: Amides - administration & dosage; Amides - pharmacology; Animals; Antiviral Agents - administration & dosage; Antiviral Agents - pharmacology; Avian bornavirus; Bird Diseases - virology; Borna Disease - drug therapy; Borna Disease - virology; Borna disease virus; Borna disease virus - genetics; Bornaviridae - drug effects; Bornaviridae - genetics; Cell Line; Cercopithecus aethiops; Favipiravir; Microbial Sensitivity Tests; Pyrazines - administration & dosage; Pyrazines - pharmacology; Quail; Replication; RNA, Viral - analysis; Time Factors; Vero Cells; Viral Load - drug effects; Virus Replication - drug effects; Replication; Avian bornavirus; Borna disease virus; Favipiravir

Bornaviruses, non-segmented, negative-strand RNA viruses, are emerging agents with the potential for causing various types of neurological symptoms. Previous studies have shown that ribavirin, a nucleic acid analog with broad-spectrum antiviral activity, has a potent antiviral effect on infections w...