A genetically engineered Plasmodium falciparum parasite vaccine provides protection from controlled human malaria infection

• Published in: Science translational medicine Vol. 14; no. 659; p. eabn9709
• Main Authors: Murphy, Sean C, Vaughan, Ashley M, Kublin, James G, Fishbauger, Matthew, Seilie, Annette M, Cruz, Kurtis P, Mankowski, Tracie, Firat, Melike, Magee, Sara, Betz, Will, Kain, Heather, Camargo, Nelly, Haile, Meseret T, Armstrong, Janna, Fritzen, Emma, Hertoghs, Nina, Kumar, Sudhir, Sather, D Noah, Pinder, Leeya F, Deye, Gregory A, Galbiati, Shirley, Geber, Casey, Butts, Jessica, Jackson, Lisa A, Kappe, Stefan H I
• Format: Journal Article
• Language: English
• Published: United States 24.08.2022
• Subjects: Animals; Humans; Insect Bites and Stings - chemically induced; Malaria - prevention & control; Malaria Vaccines; Malaria, Falciparum - parasitology; Malaria, Falciparum - prevention & control; Parasites; Plasmodium falciparum - genetics; Sporozoites - genetics; Vaccines, Attenuated

Genetically engineered live sporozoites constitute a potential platform for creating consistently attenuated, genetically defined, whole-parasite vaccines against malaria through targeted gene deletions. Such genetically attenuated parasites (GAPs) do not require attenuation by irradiation or concom...