Serum sclerostin levels associated with lumbar spine bone mineral density and bone turnover markers in patients with postmenopausal osteoporosis

• Published in: Chinese medical journal Vol. 126; no. 13; pp. 2480 - 2484
• Main Authors: XU, Xiao-juan, SHEN, Lin, YANG, Yan-ping, LU, Fu-rong, ZHU, Rui, SHUAI, Bo, LI, Cheng-gang, WU, Man-xiang
• Format: Journal Article
• Language: English
• Published: China Department of Integrated Traditional Chinese Medicine and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China 05.07.2013
• Subjects: Aged; Bone Density; Bone Morphogenetic Proteins - blood; Bone Remodeling; Collagen Type I - blood; Female; Genetic Markers; Humans; Lumbar Vertebrae; Middle Aged; Osteoporosis, Postmenopausal - blood; Osteoporosis, Postmenopausal - metabolism; Peptide Fragments - blood; Peptides - blood; Procollagen - blood; 患者; 硬化; 绝经后; 腰椎; 蛋白水平; 血清; 骨密度; 骨质疏松症; bone mineral density; postmenopausal osteoporosis; sclerostin

Background Sclerostin, expressed exclusively by osteocytes, is a negative regulator of bone formation. To gain insights into the action of sclerostin in postmenopausal osteoporosis, we evaluated serum sclerostin levels in postmenopausal women and investigated its possible associations with bone turn...