Genetic alterations on chromosome 16 and 17 are important features of ductal carcinoma in situ of the breast and are associated with histologic type

• Published in: British Journal of Cancer Vol. 81; no. 8; pp. 1410 - 1418
• Main Authors: VOS, C. B. J, TER HAAR, N. T, ROSENBERG, C, PETERSE, J. L, CLETON-JANSEN, A.-M, CORNELISSE, C. J, VAN DE VIJVER, M. J
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.12.1999
• Subjects: Alleles; Biological and medical sciences; Blotting, Southern; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Carcinoma, Intraductal, Noninfiltrating - genetics; Carcinoma, Intraductal, Noninfiltrating - pathology; Chromosomes, Human, Pair 16; Chromosomes, Human, Pair 17; Female; Genetic Markers; Gynecology. Andrology. Obstetrics; Humans; Loss of Heterozygosity; Mammary gland diseases; Medical sciences; Microsatellite Repeats; Nucleic Acid Hybridization; Regular; Tumors; Chromosomal aberration; Human; Ductal carcinoma; Carcinoma in situ; Malignant tumor; Carcinogenesis; Polymerase chain reaction; Mammary gland diseases; Pathology; Gene amplification; Comparative genomic hybridization; Loss of heterozygosity; Histological type; Cytogenetics; Mammary gland; Molecular biology; Southern blotting; Chromosome 16; Chromosome 17

We analysed the involvement of known and putative tumour suppressor- and oncogene loci in ductal carcinoma in situ (DCIS) by microsatellite analysis (LOH), Southern blotting and comparative genomic hybridization (CGH). A total of 78 pure DCIS cases, classified histologically as well, intermediately...